Anticoagulation Effect and Bleeding Risk of Combination Therapy with SAFI and Aspirin
GENG Shi-han1, XU Meng-xi1, LIU Xiao-guang2, LI De-kun2, JING Xiao-hui1, ZHANG Yan-jun1, ZHOU Da-zheng2*, ZHUANG Peng-wei1*
1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. Tianjin Tasly Pride Pharmaceutical Company Limited, Tianjin 300402, China
Abstract��OBJECTIVE To explore the curative effect of combination therapy with salvianolate injection (SAFI) and aspirin on anti-platelet aggregation and blood coagulation function, provide the experimental evidence for clinical consequence use of combination therapy with traditional Chinese medicine and western medicine. METHODS The bleeding time was measured by cutting tail evaluating of combination of drugs; platelet maximum aggregation rate induced by ADP, AA, collagen and thrombin in rats was determined by absorbance method using a microplate reader; blood coagulation of the four indicators were measured by the semiautomatic blood agglutination instrument. RESULTS SAFI had nearly no effects on aspirin group��s bleeding time. The effect on blood platelets aggregation compared with control group, SAFI group and aspirin group could significantly reduce platelet aggregation induced by ADP, AA, collagen and thrombin in normal rats(P��0.01). Combinative group could significantly increase aspirin group��s anti-platelet aggregation induced by ADP, AA, collagen and thrombin in normal rats(P��0.01,P��0.05). Coagulation function SAFI can reduced aspirin group��s TT after the combination therapy. CONCLUSION SAFI can increase anticoagulation effect of aspirin, and have no effect on aspirin��s bleeding risk.
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2018, Vol. 53 
