Analysis of the Application and Current Situation of Anti-Tumor Chinese Medicine Volatile Oils by Searching ��The Compilation of Chinese Medicine Standard�� Database
HAN Fei1,ZENG Lin1, WU Zhen-feng2,SHU Ji-cheng2,ZHAO Zhi-dong3,XIONG Wei1*,HOU Ji-hua3*
1. Jiangxi University of Traditional Chinese Medicine, Pharmacy College, Nanchang 330004, China; 2. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; 3. Jiangxi University of Traditional Chinese Medicine, Basic Medical College, Nanchang 330004, China
Abstract��Volatile oils are one class of the most important active ingredients in traditional Chinese medicine (TCM). In recent years, the research on the anti-tumor TCM volatile oils has received much attention. Screening of anti-tumor active site, exploration of the mechanism of action of anti-tumor and substance basis, and development of anti-tumor preparations of TCM volatile oils are the focus of current research. Twenty kinds of TCM volatile oils which have antitumor effects were selected from the ��The compilation of Chinese medicine standard�� database. Comprehensive statistics and analysis were carried out for their application, content and major components in the herbal medicines, the effective extraction parts and types of target tumors, granted patents, and marketed products, aiming to provide a theoretical basis and reference for in-depth study of anti-tumor TCM volatile oils and development of relevant preparation systems.
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HAN Fei,ZENG Lin, WU Zhen-feng,SHU Ji-cheng,ZHAO Zhi-dong,XIONG Wei,HOU Ji-hua. Analysis of the Application and Current Situation of Anti-Tumor Chinese Medicine Volatile Oils by Searching ��The Compilation of Chinese Medicine Standard�� Database. Chinese Pharmaceutical Journal, 2017, 52(15): 1376-1380.
ZHANG H T, ZHANG H R, XU S S. Effect of extracting factors on extraction rate of papaya seed oil[J]. J Anhui Agric Sci(����ũҵѧ), 2012, 40(2): 1026-1027.
[2]
LI J E, NIE S P, SHAO D Y, et al. Dynamic relationship between extraction yield and extraction time of essential oil from Mosla Chinensis Maxim cv. Jiangxiangru[J]. J Food Sci Biotechnol, 2014, 33 (3): 308-314.
[3]
YAN K L, ZHU X Q, ZHAO L. Extraction of volatile oils from Rhizoma Atractylodis Macrocephalae[J]. Chin Remed Clin(�й�ҩ�����ٴ�), 2011, 11(7): 763-767.
[4]
XUE S A, LV D S, LI B L, et al. Studies on the antitumor effect of castor oil extract[J]. China J Chin Mater Med(�й���ҩ��־), 1992, 17 (9): 560-561.
[5]
LUO M L. Study on aqueous enzymatic extraction of castor oil[D]. Changsha:Central South University of Foresty and Technology, 2014.
[6]
TIAN J B, FENG W Y. Study on in vitro antitumor effect of polyphase liposome of artemisia oil[J]. J Mod Med Health,2012, 28 (14): 2081-2082.
[7]
FENG W Y, TIAN J. Study on volatile oil content detection and extraction technology[J]. J Luzhou Med Coll(����ҽѧԺѧ��), 2001, 24 (5): 455-456.
[8]
XU P X, JIA W M, BI L W, et al. Studies on components and quantity of essential oil from Mentha piperita L. produced in XIN Jiang,China[J]. Chem Ind Forest Prod, 2003, 23(1): 43-45.
[9]
GUO X Y. Study on chemical composition perfume property and activities of star anise oil[D]. Hangzhou: Zhejiang University of Technology, 2013.
[10]
CAI D J, ZHU Y B, MAO L C. Supercritical CO2 extraction and GC-MS analysis of star anise oil components[J]. Chin Food Addit(�й�ʳƷ��Ӽ�), 2008, (4): 143-147,138.
[11]
GUAN W Q, LI S F, HOU C X, et al. Determination and correlation of solubilities of clove oil components in supercritical carbon dioxide[J]. J Chem Ind Eng (China), 2007, 58 (5): 1077-1081.
[12]
CHEN L P, ZHANG H P, CHEN G, et al. Cinnamon oil composition analysis and in vitro antitumor activity of cinnamic aldehydeon China[J]. J Microecology, 2012, 24 (4): 327-330.
[13]
WANG T, ZHANG J C, CHEN Y, et al. Comparison of antioxidative and antitumor activities of six flavonoids from Epim edium Koreanum[J]. China J Chin Mater Med(�й���ҩ��־), 2007, 32 (8): 715-718.
[14]
GAO Y Q. Antibacterial and Antitumor Activity of Synthesized ��-Pinene Derivatives[D]. Beijing: Chinese Forestry Research Institute, 2013.
[15]
DUAN W G, CHEN X P, WANG L L, et al. Analysis of chemical components of turpentine and hydrogenated products by GC-MS method[J]. Linchan Chem Communica(�ֲ�����ͨѶ), 2000, 34 (4): 7-11.
[16]
WU Y F, QIN S R, LIU S Q. The research status of volatile oil in perilla frutescens[J] . Lishizhen Med Chin Med(ʱ���ҽ��ҩ), 2007, 18 (8): 2019-2020.
[17]
CENG J H, HUANG F X, LIAO Y. New progress of content determination methods and anti-tumor effect of zedoary oil[J]. Anti-tumor Pharm, 2012, 2 (1): 19-22.
[18]
QIAN S H, WANG Y X, KANG S H, et al. Dried tangerine or orange peel extract in vitro antitumor research[J]. J Tradit Chin Med(��ҩ��), 2003, 26 (10): 744-745.
[19]
DOU Y Q, LI D S, LIU S Q. Non-dominant components of citronella oil and their tumorostatic activity[J]. Shanxi Med J(ɽ��ҽҩ��־), 2005, 34 (5): 375-376.
[20]
ZHAO J F, LIU Z, ZHANG Y. Determination of main compounds in citronella oil by RP-HPLC[J]. Chin Food Additives(�й�ʳƷ��Ӽ�), 2014,7(1): 179-183.
[21]
ZHOU Z W, LIU P X. Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri[J]. China J Chin Mater Med(�й���ҩ��־), 2005, 30 (17): 1309-1313.
[22]
LIU Y E,LIU L L,GUO T. The overview in antineoplastic study of Panax notoginseng[J]. Lishizhen Med Chin Med(ʱ���ҽ��ҩ), 2008, 19 (4): 1015-1016.
[23]
YU J,QI Y,LUO G, et al. Extraction and analysis of the essential oil in pogostemon cablin by enzymatic hydrolysis and inhibitory activity against Hela cell proliferation[J]. J Chin Med Mater (��ҩ��), 2012, 35(5): 796-799.
[24]
SONG X L. Study on anti-tumor effection of Lavender angustifolia Mill.effective components and their mechanism[D]. Jilin: Yanbian University, 2012.
[25]
DOU H J, TIAN N Q, CHEN Y M, et al. Xinjiang lavender oil production main ingredient content determination[J]. J Flavors Cosmetics, 1995,2(1):20-24.
[26]
XIAO Z X, JIANG M M, WANG X J. Study on functional and pharmacological progress of almond[J]. Almondprocessing Agricultural Products, 2011,11(1): 71-73.
[27]
LI H. Research of chemical constituents and their bioactivity of hydnocarpus hainainanensis and antiaris toxicaria[D]. Shandong:Qingdao University of Science and Technology, 2010.
[28]
QIAN H H, HU Y D. Progress of research on the mechanism of artemisinins anticancer activity[J]. Chin J Cancer Prev Treat(�л�����������־), 2006, 13 (11): 867-869.
[29]
JIANG L Y, LIU G M, CHEN K X. Advances in study on icariin extraction, separation, and its anti-tumor mechanism[J]. Drugs Clinic, 2011, 26 (5): 353-358.
[30]
LIN H. Effect of zedoary turmeric oil and some components on chronic myelocytic leukemia and its mechanism[D]. Chongqing:Third Military Medical University, 2004.
[31]
LI N. Dried tangerine or orange peel more methoxy flavone antitumor function and mechanism research[D].Beijing: Beijing University of Chinese Medicine, 2007.
2017, Vol. 52 
