Abstract��OBJECTIVE To optimize the film-ultrasonic technique for preparing nicotinate-curcumin nanoparticles.METHODS An HPLC method was established for determination of nicotinate-curcumin. Using the entrapment efficiency of nicotinate-curcumin as the evaluation indicator, the optimum excipient formula was selected through the Box-Bebnken reponse surface design of three factors (amounts of nicotinate-curcumin and lecithin and concentration of tween-80) at three levels. RESULTS With the established optimal formula, ie 80 mg stearic acid,150 mg lecithin and 20 mL tween-80 (0.6��), the entrapment efficiency of nicotinate-curcumin approached 65��. The mean particle size was 190 nm. CONCLUSION The nicotinate-curcumin nanoparticles prepared by the film ultrasonic technique optimized by central composite design test have high entrapment efficiency, indicating that the technique is feasible.
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GUO Jing-yi, WANG Peng, HU Man, HE Qun, LIN Li-mei, LIAO Duan-fang. Excipient Formula Research of Nicotinate-Curcumin nanoparticles Prepared by Film Ultrasonic Method. Chinese Pharmaceutical Journal, 2017, 52(6): 462-467.
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2017, Vol. 52 
