Abstract��Low grade inflammation has recently emerged as a common underlying cause of many chronic diseases. Heart disease, type 2 diabetes, Alzheimer��s disease and many types of cancer have all been associated with chronic inflammation. Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Insulin resistance is a key component in the development of diabetes mellitus which is caused by inflammation, and throughout the whole process of diabetes. In recent years, research on traditional Chinese medicine treatment of diabetes has got lots of achievements, and makes a further analysis about insulin resistance of diabetic, while has profound significance in the treatment of diabetes in the future. Insulin resistance can be improved with Chinese herb medicine using compound, single herbal drug and its extracts. This review focuses on the pathogenesis of inflammation and insulin resistance, and the effects of Chinese herb medicine on insulin resistance in diabetes.
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NIE Xu-qiang,ZHANG Dan-dan, ZHANG Han. Inflammation, Insulin Resistance and Traditional Chinese Medicine Treatment of Diabetes Mellitus. Chinese Pharmaceutical Journal, 2017, 52(1): 1-7.
BRUTON J D, LEMMENS R, SHI C L, et al. Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion. FASEB J, 2003,17(2):301-303.
RAMALINGAM L, OH E, THURMOND D C. Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates. Cell Mol Life Sci, 2013,70(16):2815-2834.
LIN H V, DOMENICO A. Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes. J Biol Chem, 2011, 286(11):9797-9804.
SALTIEL A R, KAHN C R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 2001, 414(6865):799-806.
TATULIAN S A. Structural dynamics of insulin receptor and transmembrane signaling. Biochemistry, 2015, 54(36):5523-5532.
WHITE M F. IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity. Diabetes Obes Metab, 2014, 16(Suppl 1):4-15.
KANG S, TSAI L T, ROSEN E D. Nuclear mechanisms of insulin resistance . Trends Cell Biol, 2016, 26(5):341-351.
RENSTR M F, BUR�FN J, SVENSSON M, et al. Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes. Metabolism, 2007, 56(2):190-198.
VOGT P K, HART J R, GYMNOPOULOS M, et al. Phosphatidylinositol 3-kinase:the oncoprotein. Curr Top Microbiol Immunol, 2010, 347(347):79-104. MYERS M G J R, BACKER J M, SUN X J, et al. IRS-1 activates phosphatidylinositol 3��-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci USA, 1992, 89(21):10350-10354. DUCLUZEAU P H, FLETCHER L M, WELSH G I, et al. Functional consequence of targeting protein kinase B/Akt to GLUT4 vesicles. J Cell Sci, 2002,115(Pt 14):2857-2866. LEGUISAMO N M, LEHNEN A M, MACHADO U F, et al. GLUT4 content decreases along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome. Cardiovasc Diabetol,2012,11(5):100. HUSSEY S E, MCGEE S L, GARNHAM A, et al. Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes. Diabetes Obes Metab, 2012,14(8):768-771. HARDIE D G, ROSS F A, HAWLEY S A. AMPK:a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol, 2012, 13(4):251-262. LEE-YOUNG R S, BONNER J S, MAYES W H, et al. AMP-activated protein kinase (AMPK)��2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle. Diabetologia, 2013, 56(3):608-617. GUO Y, JIN M, TANG Y, et al. AMP-activated kinase ��2 deficiency protects mice from denervation-induced skeletal muscle atrophy . Arch Biochem Biophys, 2016, 600:56-60. HAWLEY S A, PAN D A, MUSTARD K J, et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab, 2005, 2(1):9-19. FISHER J S. Potential role of the AMP-activated protein kinase in regulation of insulin action. J Cell Sci, 2006, 2(3):68-81. LIONG S, LAPPAS M. Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women. J Physiol Biochem, 2015, 71(4):703-717. FILLMORE N, JACOBS D L, MILLS D B, et al. Chronic AMP-activated protein kinase activation and a high-fat diet have an additive effect on mitochondria in rat skeletal muscle. J Appl Physiol, 2010, 109(2):511-520. HOTAMISLIGIL G S, SHARGILL N S, SPIEGELMAN B M. Adipose expression of tumor necrosis factor-alpha:direct role in obesity-linked insulin resistance. Science, 1993, 259(5091):87-91. KHODABANDEHLOO H, GORGANI-FIRUZJAEE S, PANAHI S, et al. Molecular and cellular mechanisms linking inflammation to insulin resistance and ��-cell dysfunction . Transl Res, 2015, 167(1):228-256. ODEGAARD J I, CHAWLA A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science, 2013, 339(6116):172-177. CHEN L, CHEN R, WANG H, et al. Mechanisms linking inflammation to insulin resistance . Int J Endocrinol, 2015, 2015:508409. AMERICAN DIABETES ASSOCIATION. Diagnosis and classification of diabetes mellitus. Diabetes Care, 2011, 34(supplement-1):62-69. NANDITHA A, MA R C, RAMACHANDRAN A, et al. Diabetes in Asia and the pacific:implications for the global epidemic . Diabetes Care, 2016, 39(3):472-485. YANG W, LU J, WENG J, et al. Prevalence of diabetes among men and women in China. N Engl J Med, 2010,362(12):1090-1101. ROSENSTOCK J, SHENOUDA S K, BERGENSTAL R M, et al. Baseline factors associated with glycemic control and weight loss when exenatide twice daily is added to optimized insulin glargine in patients with type 2 diabetes. Diabetes Care, 2012, 35(5):955-958. WANG Z Z. The Study and Application of Exercise Prescription in the Early Stage of Diabetes(����ǰ����Ⱥ�˶������о���Ӧ��). Beijing:Beijing Sport University Press, 2010:41. LARSEN C M, FAULENBACH M, VAAG A, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med,2007, 356(15):1517-1526. DONATH M Y, SHOELSON S E. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol, 2011,11(2):98-107. LARSEN C M, FAULENBACH M, VAAG A, et al. Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care, 2009, 32(9):1663-1668. XIA X, YAN J, SHEN Y, et al. Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. PLoS One, 2011, 6(2):e16556. MA H, HU Y, ZOU Z, et al. Antihyperglycemia and antihyperlipidemia effect of protoberberine alkaloids from rhizoma coptidis in HepG2 cell and diabetic KK-Ay mice. Drug Dev Res, 2016,77(4):163-170. SHUANG J, DU P, AN L, et al. Anti-diabetic effect of Coptis chinensis polysaccharide in high-fat diet with STZ-induced diabetic mice . Int J Biol Macromol, 2013, 55(3):118-122. CUI L, LIU M, CHANG X, et al. The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic mice . Biomed Pharmacother, 2016, 81:111-1192. SUKSOMBOON N, POOLSUP N, PUNTHANITISARN S. Effect of Aloe vera, on glycaemic control in prediabetes and type 2 diabetes:a systematic review and Meta-analysis. J Clin Pharm Ther, 2016,41(2):180-188. CHEN W X, YANG M, YU D W,et al. Hypoglycemic effect and mechanism of the ginseng glycopeptide in diabetic rats with QI and Yin Deficiency . Chin Pharm J(�й�ҩѧ��־), 2014, 49(21):1903-1907. YU X C, YANG W, WU B L, et al. Predication of anti-oiabetes effects of Corydalis yanhusuo alkaloids with pharmacological network technology and experimental validation in ICR mice . Chin Pharm J(�й�ҩѧ��־), 2014, 49(11):913-918. Ch. P(2015) Vol ��(�й�ҩ��2015���.һ��). 2015:446, 925, 1076, 1124, 1139, 1283, 1430-1433, 1627, 1719. YANG Z, WANG L, FENG Z, et al. Evaluating the antidiabetic effects of Chinese herbal medicine:Xiao-Ke-An in 3T3-L1 cells and KKAy mice using both conventional and holistic omics approaches. BMC Complement Altern Med, 2015, 15(1):1-12. LIN Y J, HO T J, YEH Y C, et al. Chinese herbal medicine treatment improves the overall survival rate of individuals with hypertension among type 2 diabetes patients and modulates in vitro smooth muscle cell contractility. PLoS One, 2015, 10(12):e0145109. LEE S Y, LAI F Y, SHI L S, et al. Rhodiolacrenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway. Phytomedicine, 2015,22(4):477-486. FARSI E, AHMAD M, HOR S Y, et al. Standardized extract of Ficus deltoidea stimulates insulin secretion and blocks hepatic glucoseproduction by regulating the expression of glucose-metabolic genes in streptozitocin-induced diabetic rats. BMC Complement Altern Med, 2014,14(1):1-13. PANG B, ZHOU Q, ZHAO T Y, et al. Innovative thoughts on treating diabetes from the perspective of traditional Chinese medicine. Evid Based Complement Alternat Med, 2015,2015:905432. WEN-CHIN Y, SRINIVAS N, PER BENDIX J, et al. Complementary and alternative medicine for diabetes. Evid Based Complement Alternat Med, 2013, 2013(6):568-579. LI N, LIU Q, LI X J, et al. TCM formula Xiaoyaosan Decoction improves depressive-like behaviors in rats with type 2 diabetes. Evid Based Complement Alternat Med, 2015,2015:415243. CAI H, LIAN L, WANG Y, et al. Protective effects of Salvia miltiorrhiza injection against learning and memory impairments in streptozotocin-induced diabetic rats. Exp Ther Med, 2014, 8(4):1127-1130. ZHANG H M, LIANG F X, CHEN R. Ancient records and modern research on the mechanisms of Chinese herbal medicines in the treatment of diabetes mellitus. Evid Based Complement Alternat Med, 2015, 2015:1-14. ALINEJAD-MOFRAD S, FOADODDINI M, SAADATJOO S A, et al. Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects:a randomized controlled-trial. J Diabetes Metab Disord, 2015,14(1):1-7. LI Z, GENG Y N, JIANG J D, et al. Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus. Evid Based Complement Alternat Med, 2014, 2014(1):71-80. VAREDA P M. Myrcia bella leaf extract presents hypoglycemic activity via PI3k/Akt insulin signaling pathway. Evid Based Complement Alternat Med, 2014, 2014(1):133. YANG J, MAO Q X, XU H X, et al. Tea consumption and risk of type 2 diabetes mellitus:a systematic review and Meta-analysis update. BMJ Open, 2014, 4(7):e005632. HEEYOUNG C, PATRICK G. Can tea extracts exert a protective effect against diabetes by reducing oxidative stress and decreasing glucotoxicity in pancreatic ��-cells . Diabetes Metab J, 2015,39(1):27-30. NIE X Q, CHEN H H, ZHANG J Y, et al. Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways. Acta Pharmacol Sin(�й�ҩ��ѧ��), 2016, 37(4):483-496.