Comparison of the Properties of Curcumin Solid Dispersions Prepared by Different Technologies
SHI Nian-qiu1,2, ZHANG Yong 2, FENG Bo1, LI Zheng-qiang2, QI Xian-rong3*
1. Jilin Medical University, Jilin 132013, China; 2. School of Life Science, Jilin University, Changchun 130012,China; 3. School of Pharmaceutical Science, Peking University, Beijing 100191, China
Abstract��OBJECTIVE To prepare curcumin solid dispersions by different preparation technologies and compare their properties. METHODS Curcumin/poloxamer 407 solid dispersions were prepared by freeze-drying, co-precipitation and microwave/quench cooling methods, respectively. Internal properties of obtained solid dispersion were analyzed by SEM, DSC, XRD and FT-IR. The improvement effect on the insolubility of curcumin by making it into solid dispersions by different technologies was characterized by dissolution and solubility experiments. RESULTS Curcumin was dispersed in solid dispersions in micro-crystal form. Compared with other technologies, microwave/quench cooling method could significantly improve the solubility and dissolution of insoluble curcumin. CONCLUSION The study provides reference for choice of applicable production technology for solid dispersions of insoluble Chinese traditional medicine curcumin.
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SHI Nian-qiu, ZHANG Yong, FENG Bo, LI Zheng-qiang, QI Xian-rong. Comparison of the Properties of Curcumin Solid Dispersions Prepared by Different Technologies. Chinese Pharmaceutical Journal, 2016, 51(10): 821-826.
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2016, Vol. 51 
