HE Jun1, 2, CHEN Zhong1, YANG Ya-nan1, JIANG Jian-shuang1, FENG Zi-ming1, ZHANG Pei-cheng1*
1.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; 2.Dapartment of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China
Abstract��
OBJECTIVE To study the chemical constituents of the aqueous extract of Carthamus tinctorius. METHODS Compounds were isolated by a combination of various chromatographic techniques including column chromatography on macroporous resin and Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by physiochemical properties and spectral analysis. RESULTS Twelve compounds were isolated and identified as(2E, 8E)-12R- tetradecadiene-4, 6-diyne-1, 12, 14-triol(1), (8Z)-decaene-4, 6-diyn-1-O-��-D-glucopyranoside(2), (8E)-decaene-4, 6-diyn-1-O-��-D-glucopyranoside(3), (2S)-4��, 5, 6, 7-tetrahydroxyflavavone 6-O-��- D-glucoside(4), p-hydroxybenzoic acid(5), 3-hydroxy-4-methoxybenzoic acid(6), dihydrophaseic acid methyl ester-3-O-��-D-glucoside(7), dihydrophaseic acid methyl ester(8), 4-hydroxy benzaldehyde(9), N, N��-dicoumaroyl-putrescine(10), 4-(4��-hydroxyphenyl)but-3-en-2-one(11) and 4-hydroxyacetophenone(12).CONCLUSION Compounds 1, 3-4, 6, 8, and 10 are isolated from this plant for the first time. The absolute configuration and 13C-NMR data of compound 1 are for the first time reported.
HE Jun-,
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.Chemical Constituents from Aqueous Extract of Carthamus tinctorius[J] Chinese Pharmaceutical Journal, 2014,V49(6): 455-458
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