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�й�ҩѧ��־ 2014, Vol. 49 Issue (6) :455-458    DOI: 10.11669/cpj.2014.06.004
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1.��Ȼҩ����������빦�ܹ����ص�ʵ����, �й�ҽѧ��ѧԺ-����Э��ҽѧԺҩ���о���, ���� 100050;
2.�����Ѻ�ҽԺҩѧ��, ���� 100029
HE Jun1, 2, CHEN Zhong1, YANG Ya-nan1, JIANG Jian-shuang1, FENG Zi-ming1, ZHANG Pei-cheng1*
1.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China; 2.Dapartment of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China

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ժҪ Ŀ�� �Ժ컨ˮ��ȡ���еĻ�ѧ�ɷֽ����о������� ͨ�����������֬��Sephadex LH-20������HPLC�ȶ���ɫ�׽��з��봿��, ���������ʺͲ������ݽ��м�������� �Ӻ컨ˮ�����з���õ���12��������, �ֱ�Ϊ(2E, 8E)-12R-tetradecadiene-4, 6-diyne-1, 12, 14-triol(1), (8Z)-decaene-4, 6-diyn-1-O-��-D-glucopyranoside(2), (8E)-decaene-4, 6-diyn-1-O-��-D-glucopyranoside(3), (2S)-4��, 5, 6, 7-���ǻ������ͪ 6-O-��-D-�����������(4), ���ǻ�������(5), �������(6), dihydrophaseic acid methyl ester-3-O-��-D-glucoside(7), dihydrophaseic acid methyl ester(8), ���ǻ�����ȩ(9), N, N��-dicoumaroyl-putrescine(10), 4-(4��-�ǻ�����)-��-3-ϩ-2-ͪ(11), ���ǻ�����ͪ(12)������ ������1, 3��4, 6, 8, 10Ϊ�״δӺ컨�з���õ�, ���״α���������1�ľ��Թ��ͼ�̼�����ݡ�
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�ؼ����� �컨   ˮ����   (2E   8E)-12R-tetradecadiene-4   6-diyne-1   12   14-triol   (8Z)-decaene-4   6-diyn-1-O-��-D-glucopyranoside   (8E)-decaene-4   6-diyn-1-O-��-D-glucopyranoside   �ṹ����     
Abstract�� OBJECTIVE To study the chemical constituents of the aqueous extract of Carthamus tinctorius. METHODS Compounds were isolated by a combination of various chromatographic techniques including column chromatography on macroporous resin and Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by physiochemical properties and spectral analysis. RESULTS Twelve compounds were isolated and identified as(2E, 8E)-12R- tetradecadiene-4, 6-diyne-1, 12, 14-triol(1), (8Z)-decaene-4, 6-diyn-1-O-��-D-glucopyranoside(2), (8E)-decaene-4, 6-diyn-1-O-��-D-glucopyranoside(3), (2S)-4��, 5, 6, 7-tetrahydroxyflavavone 6-O-��- D-glucoside(4), p-hydroxybenzoic acid(5), 3-hydroxy-4-methoxybenzoic acid(6), dihydrophaseic acid methyl ester-3-O-��-D-glucoside(7), dihydrophaseic acid methyl ester(8), 4-hydroxy benzaldehyde(9), N, N��-dicoumaroyl-putrescine(10), 4-(4��-hydroxyphenyl)but-3-en-2-one(11) and 4-hydroxyacetophenone(12).CONCLUSION Compounds 1, 3-4, 6, 8, and 10 are isolated from this plant for the first time. The absolute configuration and 13C-NMR data of compound 1 are for the first time reported.
Keywords�� Carthamus tinctorius,   aqueous extract,   (2E, 8E)-12R-tetradecadiene-4, 6-diyne-1, 12, 14-triol ,   (8Z)-decaene-4, 6-diyn-1-O-��-D-glucopyranoside,   (8E)-decaene-4, 6-diyn-1-O-��-D-glucopyranoside,   structural identification     
�ո�����: 2013-05-30;
��������:���ش���ҩ���ơ��Ƽ��ش�ר��(2012ZX09301002-001003)
ͨѶ���� �����, ��, �о�Ա, ��ʿ����ʦ �о�����:������Ȼ����ķ�����ϳ� Tel:(010)63165231 E-mail:pczhang@imm.ac.cn     Email: pczhang@imm.ac.cn
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�վ�, , ������ .�컨ˮ��ȡ��Ļ�ѧ�ɷ��о�[J]  �й�ҩѧ��־, 2014,V49(6): 455-458
HE Jun-, , CHEN Zhong- etc .Chemical Constituents from Aqueous Extract of Carthamus tinctorius[J]  Chinese Pharmaceutical Journal, 2014,V49(6): 455-458
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