Abstract��
OBJECTIVE To synthesize the platinum-based anti-tumor drug miriplatin. METHODS Miriplatin was synthesized from K4PtCl4. K4PtCl4was reacted with sodium nitrite to give the K4Pt(NO2)4 solution which reacted with(1R,2R)-1,2-cyclohexanediamine thus resulting in the key intermediate Pt(C6H14N2)(NO2)2. The key intermediate was subsequently reacted with hydrazine sulfate and sodium myristate in n-butanol to give the target compound. The structure of the target compound was identified by elemental analysis, ESI-MS, FT-IR, 1H-NMR, thermal analysis and specific optical rotation measurement. RESULTS The structure of the synthesized compound was consistent with the title compound, and the yield was about 61%. CONCLUSION This study provides a novel synthesis process for miriplatin.
WANG Qing-Kun-,
ZHOU Li-Min-,
PU Shao-Ping- etc
.Synthesis of Miriplatin, A Novel Platinum-Based Antitumor-Drug[J] Chinese Pharmaceutical Journal, 2013,V48(18): 1594-1595
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2013, Vol. 48 
