目的介绍香菇多糖化学及抗肿瘤作用的研究进展，为研究开发及临床应用提供参考。方法根据国内外文献，进行归纳、分析加以综述，较为全面地介绍近年来对香菇多糖的提取纯化、结构分析、抗肿瘤作用等方面的研究进展。结果香菇多糖提取纯化方法不同，其多糖组成及结构差异较大，主要体现为同多糖(葡聚糖)和杂多糖两种形式。其抗肿瘤作用主要涉及增强免疫作用、抑制肿瘤生长作用、协同化疗药物抗肿瘤等方面。结论香菇多糖的化学特性与抗肿瘤作用有密切关系，关于香菇多糖的构效关系还需要进一步的深入研究，从而更好地为香菇多糖的综合开发应用提供科学依据。
Abstract
OBJECTIVE To introduce the progress on the study of lentinan chemistry and anti-tumor effect and provide references for research and clinical applications. METHODS Reviewed and analyzed many literatures of lentinan, summarized them compressively and introduced the progress on the extraction and purification of lentinan, structural analysis and anti-tumor effect in recent years. RESULTS As the extraction and purification methods for lentinan were different, the polysaccharide compositions and structures were different, and the main forms were homopolysaccharide(glucan) and heteropolysaccharide. And its anti-tumor effects were related to immune enhancement, inhibition of tumor growth effect, synergistic anti-tumor chemotherapy and so on. CONCLUSION Chemical properties of lentinan is closely related with the anti-tumor effect, and further in-depth research on the structure-activity relationships of lentinan is needed to provide better scientific basis for the comprehensive development and application of lentinan.
关键词
香菇 /
多糖 /
化学结构 /
抗肿瘤
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Key words
Lentinus edodes /
polysaccharide /
chemical structure /
anti-tumor
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中图分类号：
Q935
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参考文献
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脚注
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基金
黑龙江省青年科学基金项目(QC2011C100)；中国博士后科学基金项目(2012M520761)
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