1.Jinling Pharmaceutical Technology Center Co., Ltd, Nanjing 210009, China; 2.Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
Abstract��
ObjectiveTo prepare metoprolol tartrate sustained-release pellets and investigate the relative bioavailability in Beagle dogs. Methods Taking aspect ratio(AR), circularity, yield, friability, fluidity as key indexes, orthogonal design was atopted to optimize the formulation,and sustained-release pellets were prepared with Surelease. Results The optimal formulation was as follows: drug loading rate 90%, adhesive 40 mL·100 g-1, spheronization rate 30 Hz, coating weight gain 12%, and aging at 60 �� for 2 h. Conclusion The prepared metoprolol tartrate sustained-release pellets are bioequivalent with Betaloc in Beagle dogs.
.Preparation of Metoprolol Tartrate Sustained-Release Pellets by Centrifugal Granulation and the Relative Bioavailability in Beagle Dogs[J] Chinese Pharmaceutical Journal, 2013,V48(14): 1174-1177
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2013, Vol. 48 
