ZHANG Bo1, JIN Yan1, GONG Hong1, MEI Dan1*, ZHONG Ming-kang2, TANG Yao3,CHEN Xiao4, LI Da kui1, Project group5
1.Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730,China;
2. Department of Pharmacy, Huashan Hospital Fudan University, Shanghai 200040,China;
3.Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041,China;
4.Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080,China; 5.Project Group
Abstract��
OBJECTIVE To assess the prescribing practice of parecoxib in surgical inpatients, especially for its efficacy and safety. METHODS This was a retrospective, multi-center survey. Based on medical records,patient’s characteristics, perioperative analgesics, postoperative pain intensity scale and drug adverse events were recorded in case report form (CRF). RESULTS Forty-one comprehensive tertiary hospitals were enrolled in this study, 3 542 inpatients were eligible, 44.7% of whom were male. The most dominant dosing regimen of parecoxib was single dose shot (62%), 27% of the enrolled patients were given more than two shots, and 4.7% of the patients were given two shots. Besides parecoxib, the analgesics used postoperatively included tramodal (17.8%), flurbiprofen axetil (14.4%), celecoxib (11.3%), fentanyl (10.2%), butorphanol (7.3%), morphine (5.1%) and pethidine (4.6%). visual analogue scale was used for pain evaluation in 24.6% of the enrolled patients. The percentage of patients who had severe pain on the operation day, postoperative day 1, postoperative day 2, and postoperative day 3 were 19.7%, 17.8%, 6.8% and 5.2%, respectivley. The incidence of drug adverse events of parecoxib was 0.2% (6/3 542), most of which were hypotension, nausea, vomiting, pruritus and rash. CONCLUSION This retrospective, multi-center survey reveals that parecoxib had a good safety profile; there is no serious adverse event in 3542 inpatient who received parecoxib postoperatively. Parecoxib is mainly used for short term, which is consistent with the current medical evidences.
ZHANG Bo-,
JIN Yan-,
GONG Hong- etc
.A Retrospective, Multi-Center survey of Parecoxib Prescribing Practice in 3 542 Surgical Inpatients[J] Chinese Pharmaceutical Journal, 2013,V48(11): 1005-1009
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2013, Vol. 48 
