Abstract��
OBJECTIVE To evaluate the effect and safety of fish oil supplementation in critically ill patients. METHODS Cochrane library�� Cochrane Register of Controlled Trials�� MEDLINE�� EMbase�� CNKI and Wanfang Data were searched for eligible literatures. The methodological quality of the included studies was evaluated and the data was analyzed by Revman5.0 software. RESULTS Eleven high-quality randomized controlled trials were included. The quality of the eleven studies was evaluated according to Jadad scale�� of which one scored four points�� one scored five points�� one scored six points�� the others all scored seven points. The result of meta-analysis indicated that fish oil supplementation could reduce the length of stay in ICU and the time of ventilation��P
ZHANG Chun-Yan,
GU Jian,
LIU Yi etc
.Fish Oil Supplementation in Critically ill Patients�� A Systematic Review [J] Chinese Pharmaceutical Journal, 2012,V47(23): 1952-1955
��
[1]
XUE D X. Nutrition and nursing of ICU critically ill patients [J]. Chin Prac Med (�й�ʵ��ҽҩ)��2009��4��23����183-184 .
[2]
FU Z M��WANG Z. Anti- inflammatory mechanism of ��-3 Polyunsaturated fatty acids[J]. Her Med (ҽҩ����)��2009��28��9����1174-1176.
[3]
BOWER R H�� CERRA F B�� BERSHADSKY B��et al. Early enteral administration of a formula (Impact Registered Trademark)supplemented with arginine�� nucleotides�� and fish oil in intensive care unit patients�� Results of a multicenter�� prospective�� randomized�� clinical trial[J]. Crit Care Med��1995��23(3)�� 436-449.
[4]
ATKINSON S�� SIEFFERT E�� BIHARI D. A prospective�� randomized�� double-blind�� controlled clinical trial of enteral immunonutrition in the critically ill [J]. Crit Care Med�� 1998��26(7)��1164-1172.
[5]
GADEK J E��DEMICHELE S J�� KARLSTAD M D��et al. Effect of enteral feeding with eicosapentaenoic acid�� gamma-linolenic acid�� and antioxidants in patients with acute respiratory distress syndrome[J].Crit Care Med��1999��27(8)��1409-1420.
[6]
GALBAN C�� MONTEJO J C�� MESEJO A��et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients [J]. Crit Care Med��2000��28(3)��643-648.
[7]
ALESSANDRO P A�� AFRA MARIA A A��JULIANA D A. Effects of enteral feeding with eicosapentaenoic acid�� ��-linolenicacid�� and antioxidants in mechanically ventilated patients with severe sepsis and septic shock[J]. Crit Care Med��2006��34(9)��2325-2333.
[8]
PIERRE S��MYRIAM T��HARAN F�� et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury [J]. Crit Care Med��2006��34(4)��1033-1038.
[9]
VERA M B�� ELIZABETH A�� CONCEICAO C�� et al. Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids�� inflammatorymarkers�� and clinical outcomes in septic patients�� Arandomized�� controlled clinical trial [J]. Crit Care�� 2010�� 14��R5.
[10]
HANS K��ARNOUT N. R��JENNEKE D. E�� et al. Clinical outcome of immunonutrition in a heterogeneous intensive care population[J]. Intensive Care Med�� 2005�� 31��4����524-532.
[11]
SIGRUN F��CHRISTIAN L��JENNY K�� et al. Fish oil supplementation in the parenteral nutrition of critically ill medical patients�� a randomized controlled trial[J]. Intensive Care Med�� 2008�� 34��8����1411-1420.
[12]
BOON S K�� SHIUMN J L��HSIN C S�� et al. Randomized�� double blind�� placebo-controlled trial of fish-oil-based lipid emulsion infusion for treatment of critically �� patients with severe sepsis[J]. Asian J Surg�� 2011�� 34(1)��1-10.
[13]
XIN Y W��WEIQIN L�� NING L�� et al. ��-3 Fat acids-supplemented parenteral nutrition decreases hyperinflammatory response and attenuates systemic disease sequelae in severe acute pancreatitis�� A randomized and controlled study [J]. Jpen��2008�� 32(3)��236-241.
[14]
XIN S B. The evolvement of nutrition in critically ill patients [J]. J Clin Pul Med (�ٴ��ο���־)��2008��13��11����1461-1463.
[15]
XIA Y P�� SU Y X . The effect of inflammation and immuno-molecular mechanism of n-3 unsaturated fatty acids [J]. Curr Immun (�ִ�����ѧ)��2004��24��6����517-519.