摘要
目的 评价鱼油营养支持对于重症患者的疗效及安全性。方法 系统检索cochrane 图书馆、Cochrane 图书馆临床对照试验资料库、美国全科医学文献数据库（MEDLINE）、生物医学与药理学文献数据库（EMbase）、中文期刊全文数据库（CNKI）和万方等数据库， 全面收集鱼油治疗重症患者的随机对照试验(RCT)，对文献进行质量评价， 并采用Revman5.0软件进行统计分析。结果 检索到鱼油用于重症患者的临床疗效及安全性的高质量的随机对照试验共11篇。按Jadad量表评分，1篇4分，1篇5分，1篇6分，其他8篇均为7分，纳入的随机对照试验研究质量均较高。Meta分析结果显示，鱼油营养支持可以降低危重患者的ICU住院天数及机械通气时间，两组比较差异具有统计学意义（P
Abstract
OBJECTIVE To evaluate the effect and safety of fish oil supplementation in critically ill patients. METHODS Cochrane library， Cochrane Register of Controlled Trials， MEDLINE， EMbase， CNKI and Wanfang Data were searched for eligible literatures. The methodological quality of the included studies was evaluated and the data was analyzed by Revman5.0 software. RESULTS Eleven high-quality randomized controlled trials were included. The quality of the eleven studies was evaluated according to Jadad scale， of which one scored four points， one scored five points， one scored six points， the others all scored seven points. The result of meta-analysis indicated that fish oil supplementation could reduce the length of stay in ICU and the time of ventilation（P
关键词
鱼油营养支持 /
重症患者 /
疗效 /
安全性 /
系统评价
{{custom_keyword}} /
Key words
fish oil supplementation /
critically ill patient /
efficacy /
safety /
systematic review
{{custom_keyword}} /
张春燕，顾健，刘一，冯婉玉.
鱼油营养支持对重症患者临床疗效及安全性的系统评价[J]. 中国药学杂志, 2012, 47(23): 1952-1955
ZHANG Chun-yan， GU Jian， LIU Yi，FENG Wan-yu.
Fish Oil Supplementation in Critically ill Patients： A Systematic Review [J]. Chinese Pharmaceutical Journal, 2012, 47(23): 1952-1955
中图分类号：
R969.3
{{custom_clc.code}}
({{custom_clc.text}})
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] XUE D X. Nutrition and nursing of ICU critically ill patients [J]. Chin Prac Med (中国实用医药)，2009，4（23）：183-184 .
[2] FU Z M，WANG Z. Anti- inflammatory mechanism of ω-3 Polyunsaturated fatty acids[J]. Her Med (医药导报)，2009，28（9）：1174-1176.
[3] BOWER R H， CERRA F B， BERSHADSKY B，et al. Early enteral administration of a formula (Impact Registered Trademark)supplemented with arginine， nucleotides， and fish oil in intensive care unit patients： Results of a multicenter， prospective， randomized， clinical trial[J]. Crit Care Med，1995，23(3)： 436-449.
[4] ATKINSON S， SIEFFERT E， BIHARI D. A prospective， randomized， double-blind， controlled clinical trial of enteral immunonutrition in the critically ill [J]. Crit Care Med， 1998，26(7)：1164-1172.
[5] GADEK J E，DEMICHELE S J， KARLSTAD M D，et al. Effect of enteral feeding with eicosapentaenoic acid， gamma-linolenic acid， and antioxidants in patients with acute respiratory distress syndrome[J].Crit Care Med，1999，27(8)：1409-1420.
[6] GALBAN C， MONTEJO J C， MESEJO A，et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients [J]. Crit Care Med，2000，28(3)：643-648.
[7] ALESSANDRO P A， AFRA MARIA A A，JULIANA D A. Effects of enteral feeding with eicosapentaenoic acid， γ-linolenicacid， and antioxidants in mechanically ventilated patients with severe sepsis and septic shock[J]. Crit Care Med，2006，34(9)：2325-2333.
[8] PIERRE S，MYRIAM T，HARAN F， et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury [J]. Crit Care Med，2006，34(4)：1033-1038.
[9] VERA M B， ELIZABETH A， CONCEICAO C， et al. Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids， inflammatorymarkers， and clinical outcomes in septic patients： Arandomized， controlled clinical trial [J]. Crit Care， 2010， 14：R5.
[10] HANS K，ARNOUT N. R，JENNEKE D. E， et al. Clinical outcome of immunonutrition in a heterogeneous intensive care population[J]. Intensive Care Med， 2005， 31（4）：524-532.
[11] SIGRUN F，CHRISTIAN L，JENNY K， et al. Fish oil supplementation in the parenteral nutrition of critically ill medical patients： a randomized controlled trial[J]. Intensive Care Med， 2008， 34（8）：1411-1420.
[12] BOON S K， SHIUMN J L，HSIN C S， et al. Randomized， double blind， placebo-controlled trial of fish-oil-based lipid emulsion infusion for treatment of critically Ⅲ patients with severe sepsis[J]. Asian J Surg， 2011， 34(1)：1-10.
[13] XIN Y W，WEIQIN L， NING L， et al. ω-3 Fat acids-supplemented parenteral nutrition decreases hyperinflammatory response and attenuates systemic disease sequelae in severe acute pancreatitis： A randomized and controlled study [J]. Jpen，2008， 32(3)：236-241.
[14] XIN S B. The evolvement of nutrition in critically ill patients [J]. J Clin Pul Med (临床肺科杂志)，2008，13（11）：1461-1463.
[15] XIA Y P， SU Y X . The effect of inflammation and immuno-molecular mechanism of n-3 unsaturated fatty acids [J]. Curr Immun (现代免疫学)，2004，24（6）：517-519.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
