目的 考察临床常用的10种药物在8种一次性滤膜上的吸附作用，为临床合理用药提供依据。方法 将一定量艾司洛尔、胺碘酮、桂哌其特、维拉帕米、克林霉素、万古霉素、头孢替安、头孢哌酮、舒巴坦钠、美罗培南等10种药物溶于250 mL 5%GS中，应用HPLC-MS/MS分别测定这些药物通过聚醚砜膜、混合纤维素酯膜、增强型混合纤维素酯膜、尼龙膜、聚偏氟乙烯膜、聚丙烯膜、尼龙编织膜、重离子膜等8种滤膜前后的药物浓度。结果 8种滤膜对10种药物均有不同程度的吸附作用：混合纤维素酯（CN-CA）膜、增强型混合纤维素酯（CN-CA-E）膜对药物的吸附作用明显高于其他6种滤膜（P<0.05）。聚醚砜(PES)膜，尼龙编织（NL-B）膜，重离子(ION)膜对10种药物的平均吸附率低于1%。聚丙烯（PP）膜、尼龙（NL）膜对10中药物平均吸附率低于1.5%。结论 PES膜、尼龙编织（NL-B）膜、ION膜对10种药物的吸附作用较小，可能对临床用药影响较小，适宜作为药用滤材。

OBJECTIVE To investigate the absorbability of 8 kinds of disposable filter membranes for infusion apparatus to 10 injectable drugs， thus to provide information for clinical medication. METHODS Each drug was separately dissolved in 250 mL 5% dextrose solution. Samples of drug solutions were collected before and after being filtered by the membranes. These samples were analyzed by HPLC-MS/MS methods. RESULTS The 8 kinds of membranes had different adsorbabilities to the 10 injectable drugs. CN-CA membrane (CN-CA) and CN-CA Enhance membrane (CN-CA-E) adsorbed more drugs than other membranes（P<0.05）. The average adsorption of PES membrane， NL-B membrane and ION membrane to the 10 drugs were lower than 1%. PP membrane and NL membrane to the 10 drugs were lower than 1.5%. CONCLUSION PES membrane， ION membrane and NL-B membrane have lower adsorbabilityies than other membranes， thus may have little influence on medical treatment. They may be suitable for clinical application.