药物非临床光安全性检测方法

刘丽 孙立 李波

中国药学杂志 ›› 2010, Vol. 45 ›› Issue (12) : 884-887.

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PDF(697 KB)
中国药学杂志 ›› 2010, Vol. 45 ›› Issue (12) : 884-887.
综述

药物非临床光安全性检测方法

  • 刘丽,孙立,李波*
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摘要

目的 对光毒性(光刺激性)、光过敏性、光致癌性和光遗传毒性等检测方法进行综述,为药物非临床光安全性检测提供参考。 方法 通过查阅与光安全性检测相关的国内外文献和指导原则,对各类光安全性检测的体内、体外方法和研究进展进行叙述和总结。 结果结论 近年来,临床上报道有很多药物具有光敏性甚至光致癌性,如补骨脂素、氟喹诺酮类药物和磺胺类药物等。药物的光安全性逐渐受到关注,对于具有潜在光安全性问题的药物,应加强临床前检测工作。

关键词

光安全性 / 光敏性 / 光毒性(光刺激性) / 光过敏性 / 光致癌性 / 光遗传毒性 / 紫外照射

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刘丽 孙立 李波. 药物非临床光安全性检测方法[J]. 中国药学杂志, 2010, 45(12): 884-887

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