摘要
目的 概要介绍土槿皮乙酸的抗肿瘤作用和可能的分子机制。方法 查阅文献,总结土槿皮乙酸体内外抗肿瘤活性的研究成果,依据作用靶点不同对其分子机制进行综述。结果 土槿皮乙酸抗肿瘤作用机制因肿瘤的种类而有所不同,它可通过抑制在某些肿瘤发生过程中异常表达的环氧化酶-2(COX-2),调节相关上下游基因和蛋白的表达,抑制肿瘤新生血管生成、阻止肿瘤细胞增殖并促进其凋亡。 结论 国内外近年来对该药抗肿瘤作用的机制研究获得了多方面的新成果,有助于我们找到新的治疗肿瘤的靶点。
关键词
土槿皮乙酸 /
抗肿瘤 /
分子机制 /
环氧化酶-2 /
凋亡
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侯丽 崔景荣.
土槿皮乙酸抗肿瘤作用及其分子机制的研究进展[J]. 中国药学杂志, 2010, 45(23): 1810-1812
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脚注
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