ZHANG Yan1�� YANG Zhao1�� JIN Hong-yu2�� SUN Lei2�� LI Xin-rong1�� WU Ai-ying1
1.Qingdao Institute for Drug Control�� Qingdao 266071�� China; 2. National Institute for the Control of Pharmaceutical and Biological Products�� Beijing 100050�� China
Abstract��
OBJECTIVE To establish a method for the determination of 19 carbamate pesticides in Chinese medicinal materials by UPLC triple-quadrupole tandem mass spectrometer. METHODS The samples were determinated by multi-reactions monitoring (MRM technology. The separation was performed on a Waters ACQUITY UPLC�j BEH C18 column with acetonitrile -0.1% formic acid (1��1 with a flow rate of 0.2 mL min-1. Ion mode was set as ESI+. RESULTS The standard curves of the 19 carbamate pesticides showed good linearity over the concentration range of 1.0-100 ��g��L-1 ��r=0.994 7-0.999 7�� respectively. The LODs of 19 carbamate pesticides were in the range of 0.02-0.46 ��g��L-1 and the average recoveries were 73.2%-119.7% at three levels. CONCLUSION The method is rapid�� sensitive and suitable for the determination of 19 carbamate pesticides in Chinese medicinal materials.
2011, Vol. 46 
