OBJECTIVE To prepare hypertonic sodium chloride dextran 70 injection and establish its standard for quality control.METHODS The composition and manufacturing technique were designed.Quality standard was established according to ChP2000 and 3 batches of product were tested.RESULTS 3 Batches of product complied with the requirements of quality standard.CONCLUSIONS The composition and manufacturing technique is rational in formula and the method of quality control is suitable.
ZHO Lin;WNG o;WNG Gung-yi;ZHO Jing-xing;ZHO Xio-yu;ZHNG Yu-hu;ZHOU Hong.
Study on Preparation and Quality Standard of Hypertonic Sodium Chloride Dextran 70 Injection [J]. Chinese Pharmaceutical Journal, 2006, 41(16): 1237-1239
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] LU D X.Preparation of Neoteric Injection(近代输液剂的制备)[M]. Beijing: Chinese Medical Science and Technology Press,1990:358-359.
[2] GRADY J J, KRAMER G C, YOUNES R N,et al. Individual patient cohort analysis of the efficacy of hypertonic saline/dextran in patients with traumatic brain injury and hypotension[J]. J Trauma,1997, 42(5 Suppl):S61-S65.
[3] ROTSTEIN O D. Novel strategies for immunomodulation after trauma:revisiting hypertonic saline as a resuscitation strategy for hemorrhagic shock[J].J Trauma,2000,49(4):580-583.