Abstract��
OBJECTIVE To compare the pharmacokinetics of 10-hydroxycamptothecin after nebulized inhalation and intravenous(iv) administration in rabbit.METHODS RP-HPLC was used to determine the concentration of HCPT in rabbit plasma.The plasma concentrations at different time after nebulized inhalation and iv administration were analyzed and estimated for pharmacokinetic parameters.RESULTS The HCPT concentrations in plasma after nebulized inhalation were obviously lower than that of iv administration group.The MRT and t1/2 after nebulized inhalation were remarkably longer than that of iv administration group,while the AUC was obviously decreased.The bioavailability was only(10.69��3.29)%.CONCLUSION The HCPT concentrations in plasma after nebulized inhalation are obviously reduced and the bioavailability is low.So this administration route can raise the therapeutic index and reduces adverse effects.
.Comparison of Pharmacokinetics of 10-Hydroxycamptothecin Between Nebulized Inhalation and Intravenous Administration in Rabbits [J] Chinese Pharmaceutical Journal, 2006,V41(16): 1255-1258
2006, Vol. 41 