Abstract��
OBJECTIVE: The pharmacokinetic characteristics of celiprolol hydrochloride and its change after different single dosing were investigated. METHOD: 100 mg,200 mg,and 400 mg celiprolol hydrochloride tablets were given orally in single dose to 9 healthy volunteers designed by 33 latin square.The plasma levels at given times were derermined by RP-HPLC.The pharmacokinetic parameters were fitted and calculated by MCPKP program.HZRESULTS:t1/2k,K,tmax,cmax and AUC of 100,200 and 400 mg dometic celiprolol hydrochloride tablets were 3.37,3.45 and 3.56h;0.24,0.21 and 0.20 h-1;3.64,3.38 and 3.87 h;177.55,501.4 and 1188.58 ng��ml-1;1615.41,4508.38 and 10828.5��g��h��L-1,respectively.CONCLUSION: With analysis of variance,the parameters such as t1/2K,K and tmax in three kinds of dosage had no singnificant difference (P>0.05),cmax and AUC did not change multipl with the increase of dosage.
1999, Vol. 34 
