Abstract��
OBJECTIVE: To study the effect of penetration enhancers on the transdermal delivery of tetracaine and find a percutaneous tetracaine formulation with short onset time. METHODS: In vitro permeability of tetracaine from various gels was studied by using Franz diffusion cells. Then a double��blinded trial was undertaken to assess the practical effects of these gels through pinprick method. RESULTS: Laurcapram could increase permeation flux of tetracaine obviously, especially when propylene glycol and ethanol were presented, but these gels showed poor anaesthetic effects with prolonged lag time. Ethanol alone did not prolong lag time and increase rapidity of action. CONCLUSION: Tetracaine gel containing ethanol would be a new formulation with ideal local anaesthetic effect.��
1997, Vol. 32 
