Abstract��
OBJECTIVE: To study the relative bioavailability between soft and solid capsules. METHODS: The single dose soft (100 mg) and solid (150 mg) capsules were administrated crossing over in 10 volunteers. A reversed phase high performance liquid chromatography was used to determine ritaminate level in human plasma. RESULTS: There were no significant difference in absorption and elimination phases between two preparations. The main pharmacokinetic parameters of soft and solid capsules were as follows. The absorption t1/2 was (1.457��0.508)h and (1.349��0.482)h respectively. The elimination t1/2 was (2.378��0.871)h and (2.744��1.097)h respectively. The time to achieve maximum plasma concentrations was (2.612��0.778)h and (2.649��0.700)h, respectively. The peak concentrations were (17.496��8.992)��g��L-1 and (16.031��7.732)��g��L-1 respectively. The mean retention times (MRT) were (3.618��0.540)h and (3.728��0.379)h, respectively. The area under curve (AUC) was (93.467��54.148)��g��h��L-1 and (89.658��45.814)��g��h��L-1 respectively. The relative bioavailability of ritaminate soft capsule to solid capsule was (169.41��29.08)%. CONCLUSION: The ritaminate soft capsules have higher bioavailability than solid ones.
1997, Vol. 32 
