目的：了解常用心血管药物不良反应发生率，评价ADRs发生的危险因素。方法：采用记录应用法对心内科 住院病人进行连续一年的前瞻性心血管药物不良反应监察。结果：1015例监察对象中，108例发生ADRs (10.64%),主要为轻、中度反应，A型反应占90.74%,中途停止治疗者占发生ADRs总数的31.84%;逻辑斯蒂单 因素、多因素回归分析显示患者的肾功能状态及合并用药数与ADRs的发生有密切相关。结论：常用心血管药物不 良反应发生率为10. 64%，逻辑斯蒂单因素、,因素回归分析有助于确定ADRs发生的危险因素。

OBJECTIVE ： To evaluate the incidence and risk factors of cardiovascular drugs-related ADRs. METHODS ： Patients hospitalized in Zhongshan and Huashan hospitals in a year，who took one or more kinds cardiovascular drugs, were observed prospectively. RESULTS-Of the 1015 patients, 108(10.64%) had ADRs. The incidence of 8 drugs was 3, 36% (propafenone), 3.9% (diltiazelm), 4.26% (nifedipine) , 5.62% (captopril)，7.16%(digoxin)，10.86% (mexiletine)，3.52% (atenolol) and 4.90% (metoprolol) respectively. Type A and B reactions accounted for 90.74% and 9.26% respectively in all ADRs patients. 34 patients(31.84%) discontinued treatment.Logistic analysis showed that the number of drugs and kideny function are closely related to ADRs. CONCLU-SION ：The incidence of cardiovascular drug-related ADRs is 10.64%. Logistic analysis helps determine risk factors of ADRs.