Abstract��
OBJECTIVE �� To evaluate the incidence and risk factors of cardiovascular drugs-related ADRs. METHODS �� Patients hospitalized in Zhongshan and Huashan hospitals in a year��who took one or more kinds cardiovascular drugs, were observed prospectively. RESULTS-Of the 1015 patients, 108(10.64%) had ADRs. The incidence of 8 drugs was 3, 36% (propafenone), 3.9% (diltiazelm), 4.26% (nifedipine) , 5.62% (captopril)��7.16%(digoxin)��10.86% (mexiletine)��3.52% (atenolol) and 4.90% (metoprolol) respectively. Type A and B reactions accounted for 90.74% and 9.26% respectively in all ADRs patients. 34 patients(31.84%) discontinued treatment.Logistic analysis showed that the number of drugs and kideny function are closely related to ADRs. CONCLU-SION ��The incidence of cardiovascular drug-related ADRs is 10.64%. Logistic analysis helps determine risk factors of ADRs.
1996, Vol. 31 
