Abstract��
OBJECTIVE:To establish a dissolution measurement method for fluconazole,and to determine the content and dissolution of fluconainzole in 4 different dosage forms. METHODS:The dissolution was measured in hydrochloride acid solution (9��1000) as medium.According to the second method described in Chinese Pharmacopoeia (1995) appendix XC,the rotational speed was 50 r��min-1,and the temperature (37.0��0.5)��.The content was measured by UV spectrophotometry at 261 nm.The calibration curve was linear (r��0.9999). RESULTS:The dissolution in 30 minutes was more than 70%,and there were no significant differences in dissolution parameters (t50,td,m) among four products (P��0.05). CONCLUSION:The method was sensitive and reliable.It may be used for the quantitative evaluation of products.
2000, Vol. 35 
