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�й�ҩѧ��־ 1996, Vol. 31 Issue (08) :470-473    DOI:
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Yang Dongxu
(Yang DX),Cheng Guifang(Cheng GF

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ժҪ Ŀ�ģ��л�����������ж��ֻ��ԣ�Ϊ���о�3�ֺϳɵ��л���������Ŀ������úͿ���̬��Ӧ����,��������Ч��ϵ��������ҩ���С��Ͷ����Զ����͵�Ӱ��;���鰷(histamine,His)������������Ӧ����(slow-reacting substance of anaphylaxis SRS-A)������������س�������Ӱ��;�����������SRS-A����ȡ��ҩ����׿�ʵ�顣�����3�ֻ������ܲ�ͬ�̶ȵ�����С��Ͷ����Զ�����(��WTBX��P��0.05��P��WTBZ����0.01)��50%������������س�����ʱ��ҩ��Ũ��(IC50)�ֱ�Ϊ��His:1.25��10-5,1.58��10-4��1.25��10-4 mol/L,��SRS-A:8.9��10-6��1.25��10-4��1.12��10-4mol/L������������ͷ�SRS-A������Ũ��:10-4mol/L�����ۣ�3ҩ��9108��������׿�������ǿ�����໯����Ļ�ѧ�ṹ�б���(B)��λ����ȡ���Ļ��������ǿ�������׿����á����ǵĿ��׼����������������His��SRS-A�������׿����ü�SRS-A�����������йء�
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Abstract�� OBJECTIVE:To study effects of seleno-organic compounds 9108,9109 and 9110 on antinflammation and antiallergy.METHODS:Mouse ear edema induced by croton oil was inhibited.The contractions induced by histamine(His) and slow-reacting substance of anaphylaxis(SRS-A) in the guinea-pig ileum were inhibited.SRS-A was abstracted from isolated sensitized guinea-pig lung and SRS-A release was inhibited.RESULTS:Seleno-organic compounds were found to inhibit mouse ear edema induced by croton oil(P��0.05 or P��0.01) and the contractions induced by His and SRS-A in the guinea-pig ileum in dose-dependent manner.IC50 values for His inhibition were 1.25��10-5,1.58��10-4 and 1.25��10-4 mol/L,for SRS-A inhibition 8.9��10-6,1.25��10-4,and 1.12��10-4 mol/L respectively.Seleno-organic compounds at dose of 10-4 mol/L inhibited SRS-A release from isolated sensitized guinea-pig lung.CONCLUSION:These results indicate that these compounds possess antimmunoinflammatory effects and 9108 is the strongest receptor antagonist among the three compounds.This mdicates that esterification at the ortho-position of the phenyl-ring(B) exhibits strong receptor antagonistic action.Antagonism of His and SRS-A receptor and inhibition of SRS-A release may play an important role in the mechanism of antinflammatory actions of these compounds.
Keywords�� seleno-organic compounds,   histamine,   SRS-A,   croton oil     
�ո�����: 1955-02-10;
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.�л���������Ŀ��׼�����̬��Ӧ����[J]  �й�ҩѧ��־, 1996,V31(08): 470-473
.Effects of seleno-organic compounds on antinflammation and antiallergy[J]  Chinese Pharmaceutical Journal, 1996,V31(08): 470-473
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