目的:为宫宁冲剂(中药制剂)提供质量控制方法。方法:采用薄层色谱法对制剂中的三七、黄芩、白芍、甘草进行了定性鉴别;以薄层扫描法测定了制剂中三七皂苷C₁(人参皂苷Rg₁)的含量。结果:薄层色谱斑点清晰;人参皂苷Rg₁在1.1μg～6.6μg范围内浓度与峰面积线性关系良好,平均回收率为98.18%,RSD为0.9%。结论:三七等药材的定性鉴别及人参皂苷Rg₁含量测定方法简便、可靠,重现性好,可作为该制剂的质量控制方法。

OBJECTIVE: To provide a method of quality control for Gongning granules (preparation of Chinese materia medica). METHOD: Thin-layer chromatography was employed for qualitative identification of the herbs of Sanqi, Huangqin, Baishao, Gancao and thin-layer chromatographic scanning was used for content determination of ginsenoside Rg₁ in the preparation. RESULT: The spots of ginsenoside Rg₁ on the TL plate had a good linear relationship between its content and area within the range of 1.1 μg～6.6 μg. The average recovery was 98.18%, and the RSD was 0.9%. CONCLUSION: The method of qualitative identification for the herbs (eg. Sanqi) and quantitative determination for ginsenoside Rg₁ can be used for quality control because of their convenience, accuracy and good reproducibility.