两种硝苯地平缓释制剂体外释放的比较

姜晓民 王铀 福岛昭二 猪爪信夫

中国药学杂志 ›› 2000, Vol. 35 ›› Issue (12) : 821-822.

中国药学杂志
中国药学杂志 ›› 2000, Vol. 35 ›› Issue (12) : 821-822.
临床药学

两种硝苯地平缓释制剂体外释放的比较

  • 姜晓民，王铀，福岛昭二，猪爪信夫
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Comparative in vitro release of two nifedipine controlled release preparations

  • JIANG Xiao-min,WANG You,SHOJI Fukushima, NUBUO Inotsume
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摘要

目的 国产天海力缓释片和日本产Adalat缓释片释放速率的比较。方法 采用日本《第13改正药局方》溶出试验第2法。结果 2种缓释片在酸性和中性2种缓冲液中的释放速率有明显差异(P＜0.05)。结论 天海力缓释片是一个具有良好释放特性的口服缓释制剂。

Abstract

OBJECTIVE To compare the in vitro release rate of Tianhaili controlled release tablets (made in China) and Adalat (made in Japan). METHOD The release test 2 in the pharnacopoeia of Japan thirteenth edition was used. RESULTS The release rate of two controlled release tablets had significant difference(P＜0.05). CONCLUSION Tianhaili controlled tablets is a preparation with good release characters.

关键词

硝苯地平 / 缓释制剂 / 释放率

Key words

nifedipine / controlled release preparation / release rate

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姜晓民 王铀 福岛昭二 猪爪信夫. 两种硝苯地平缓释制剂体外释放的比较[J]. 中国药学杂志, 2000, 35(12): 821-822
JING Xio-min;WNG You;SHOJI Fukushim;NUUO Inotsume. Comparative in vitro release of two nifedipine controlled release preparations[J]. Chinese Pharmaceutical Journal, 2000, 35(12): 821-822

参考文献

［1］Cheng X,Yao Z,Li Q.The long-term effect of nifedipine control-release tablets in parients with chronic obstructive pulmonary disease and cor pulmonale［J］.Chin J Tuberc Respir Dis.1997,20(2),84. ［2］Fu CD,Jiang XT,Hu JH,et al.Studies on oral sustained-relerse microspheres of nifedipine［J］.Acta Pharm Sin，1996,31(9)：706. ［3］Yang TH,Zhang JS,Liu GJ,et al.Studies on the controlled-release pellets of nifedipine［J］.Acta Pharm Sin，1989,24(8),622.

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