目的 制备含有补骨脂素及醋酸地塞米松的脂质体凝胶并研究其经皮吸收后体内分布，为临床新制剂的开发打下基础。方法 用均匀设计优选该脂质体凝胶的处方及制备工艺，并用扫描电镜观测其外观、大小及分布，用分子筛法结合HPLC测定其包封率，初步考察该制剂的稳定性，并以家兔为试验对象研究其皮肤刺激性，用豚鼠研究其经皮传递后主药体内分布情况。结果 由优选出的处方及工艺制备的脂质体凝胶外观圆整，分布较均匀，包封率理想，稳定性良好，与对照品相比对家兔皮肤有明显的保护作用，在豚鼠皮肤内的滞留量显著增加，是对照品的4.2倍（P＜0.01）,而全身吸收量明显降低（P＜0.05）。结论 含有补骨脂素及醋酸地塞米松的脂质体凝胶高效低毒，可望成为临床治疗白癫疯的新型外用制剂。

OBJECTIVE To study the preparation and in-vivo disposition through skin-absorption of liposomal gel including psoralen and dexamethasone acetate in order to develop a new therapeutic preparation for vitiligo. METHODS To screen the composition and preparing method using homogeneous design.Its outward appearance and size distribution were detected by scanning electron microscope (SEM).Molecular sieve and HPLC were used to study the encapsulated rate of the liposomal gel.We also observed its stability in-vitro preliminarily.Finally we tested its skin irritation and in vivo disposition through skin-absorption. RESULTS The liposomal gel had promising characters of fine-looking appearance, shallow size distribution, high encapsulated rate and good stability in vitro.Compared with the control, it had significant protective action for rabbits' skin.It produced higher accumulation of psoralen and dexamethasone acetate in skin(4.2-fold,P＜0.01) and low drug concentration in the internal organs of guinea pigs (P＜0.05). CONCLUSION The results strongly suggested that the liposomal gel including psoralen and dexamethasone acetate was valuable to be further developed as a new therapeutic preparation for vitiligo with high effect and low toxicity.