Abstract��
OBJECTIVE To study the pharmacokinetics of insulin by transdermal delivery with pulse current iontophoresis in rabbits. METHODS The release electrodes of insulin were made.The plasma concentrations of insulin and c-peptide were determined by radioimmunoassay method.The main pharmacokinetic parameters of the four groups were calculated with computer.The concentration-time data were analyzed using 3P97 Pharmacokinetic Program. RESULTS The concentration-time curves of insulin in blood conformed to a one-compartment open model after 10,20,40 u��kg-1transdermal delivery and 2.0 u��kg-1subcutaneous injection respectively.The insulin absorption in the three groups of transdermal delivery were fast and the peak plasma level appeared around 2.0 h.But the absorbtion was faster in the subcutaneous injection group and the peak plasma level appeared at 1.1 h.The insulin elimination in the transdermal delivery groups was the same as the subcutaneous injection group.The cmax,AUC,CL/F(s) and V(c)F were shown to be dose dependent in the three transdermal groups. CONCLUSION The absorption rate in the subcutaneous injection group was faster than the three groups of transdermal delivery,but the elimination was the same in all the groups.
2000, Vol. 35 
