Abstract��
OBJECTIVE To compare the pharmacokinetics and bioavailability of miocamycin under conditions of fasting and after meal. METHODS A single oral dose of miocamycin 600 mg was given to 10 healthy volunteers under the conditions of fasting and after meal in a crossover study.Serum miocamycin concentration was determined by HPLC. RESULTS The concentration-time profile of miocamycin fitted to one compartment model and the pharmacokinetic parameters were:tmax=(0.63��0.11) and (1.02��0.31) h��cmax=(2.36��0.35) and (1.82��0.32) ��g��ml-1��t1/2=(1.31��0.11) h and (2.03��0.19) h��AUC=(6.20��1.28) and (6.88��1.46) ��g��h��ml-1/sup>in fasting and after meal conditions,respectively.The absorption rate of miocamycin was delayed and the peak concentration was reduced,with a long elimitration half-time after meal.But the bioavailability of miocamycin had no significant difference. CONCLUSION Miocamycin was bioequivalence between the conditions of fasting and after meal.in terms of AUC.
.Influence of food on pharmacokinetics and bioavailability of miocamycin in normal volunteers after single oral administration[J] Chinese Pharmaceutical Journal, 2000,V35(11): 758-760
2000, Vol. 35 
