Abstract��
OBJECTIVE To explore the antidepressant actions of the ethanolic extracts of the roots of Morinda officinalis- How. METHODS The forced swimming tests in mice and rats and differential-reinforcement-of-low-rate 72 second schedule (DRL 72 s) in rats were used. RESULTS Similar to desipramine,the extracts produced significant reducation in the immobility periods in the forced swimming tests in mice and rats and elicited significant increases in reinforcers in DRL 72 s in rats. CONCLUSION These findings demonstrate that the extracts possesse antidepressant activity.
.Antidepressant effect of the ethanolic extracts of the roots of Morinda officinalis- in rats and mice[J] Chinese Pharmaceutical Journal, 2000,V35(11): 739-741