新型肠动力药普卡心利的作用及应用

林志彬 游育红

中国药学杂志 ›› 2000, Vol. 35 ›› Issue (11) : 723-725.

中国药学杂志 ›› 2000, Vol. 35 ›› Issue (11) : 723-725.
综述

新型肠动力药普卡心利的作用及应用

  • 林志彬,游育红
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摘要

目的 介绍新型的肠动力药普卡必利的胃肠道作用及应用。方法 以国外发表的文献为依据,综述介绍。结果 普卡必利具有高度选择性及特异性的5-HT 4受体激动作用,它能刺激大鼠、豚鼠及人的肠蠕动反射,增强结肠收缩,加速胃排空。能增加便秘患者的排便频率,并降低粪便硬度,主要用于治疗各种便秘及手术后胃肠道蠕动迟缓无力和假性肠梗阻。结论 普卡必利是一种新型的肠动力药。

关键词

普卡必利 / 肠动力药

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导出引用
林志彬 游育红. 新型肠动力药普卡心利的作用及应用[J]. 中国药学杂志, 2000, 35(11): 723-725

参考文献

[1]Thompson WG.Functional bowel disorders and chronic functional ab-ominal pain[J].Gastroenterol Int,1992,5:75. [2]Gattusso Jm,Kamm M.The management of constipation in adults[J].Aliment Pharmacol Ther,1993,7:847. [3]Jones M.Laxatives in chronic constipation:a statistical meta-analysis.Presented at Digestive Disease Week and 97th Aunual Meeting of the American Gastroenterology Asssociaton[C].Oriandi,Fl USA,1999:1747. [4]Emmanuel AV,Kamm MA,Roy AZ,et al.Effect of a novel prokinetic drug.R093877,on gastrointestinal transit in healthy volunteers[J].Gut,1998,42:511. [5]Grider JR,Foxx-orenstein AE,Jin JG.5-hydroxytryptamined receptor agonists the peristaltic reflex in human,rat,and guinea pig intestine[J].Gastroenterology,1998,115:370. [6]Jin JG,Foxx-orenstein AE,Grider JR,et al.Propulsion in guinea pig colon is induced by-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 re-ceptors[J].J Pharm Exp Ther,1999,288:93. [7]Briejer MR.Serotonin 5-HT4 receptors mediate the R093877-induced changes in contractile patterns in the canine colon.Presented at Diges-tive Disease Week and 97th Annual Meeting of the American Gastro-enterology Association[C].Washington DC,USA,1997,Gastroenter-ology,1997,112:A705. [8]Briejer MR,Van Daele P,Bosmans JP,et al.R093877 dose-depen-dently accelerates delayed gastric emptying in conscious dogs.Present-ed at Digestive Disease Week and 97th Annual Meeeting of the Ameri-can Gastroenterology Association[C].Washington DC,USA,1997,Gastroenterology,1997,112:A704. [9]Verhayen K.Double-blind comparison of two cisapride dose regimens with placebo in the treatment of functional constipation:a general prac-tice multicenter study[J].Curr Ther Res,1987,41:978. [10]Hermamdez A.Double-blind dose-reponse study of cisapride in the treatment of chronic functional constipation[J].Adv Ther,1998,5:121. [11]Briejer MR.R093877 induced giant migrating contraction (GMC) and alter chronic motility patterns in awake dogs[J].Neurogastroent Motil,1998,10:62.

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