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ժҪ Ŀ��:��¹�ܳ(��)׿(��)ͪ�Կ�(��)��(��)��͸Ƥ��õ�Ӱ�졣��:Ӧ�ü�С�ҷ��ƤΪ͸Ƥ��ʹ�ò�ͬŨ�ȵ��¹�ܳ(��)׿(��)ͪ��(��)��(��)��ີ�͸Ƥ��:��0.5%, 1.0%,2.0%,3.0%�¹�ܳ(��)׿(��)ͪ�Ŀ�(��)��(��)��າ��벻�� ¹�ܳ(��)׿(��)ͪ�Ŀ�(��)��(��)��າ��䣬��͸Ƥ��(P<0.05)��Բ��(P<0.01)��¹�ܳ(��)׿(��)ͪ�Կ�(��)��(��)��ີ�͸Ƥ��մٽ��Ũ��ԡ��:��ͬŨ�ȵ��¹�ܳ(��)׿(��)ͪ��Դٽ��(��)��(��)��ີ�͸Ƥ��գ��Ժ�0.5%��¹�ܳ(��)׿(��)ͪŨ�ȣ��ٿ�(��)��(��)��Ч��ѡ�

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�ؼ���� ¹�ܳ(��)׿(��)ͪ ��(��)��(��)�� ͸Ƥ��

Abstract�� OBJECTIVE:To observe the effects of Azone affecting the transdermal amount of oxaprozin. METHOD:Using simple cell method and snake skin as transdermal barrier, we determined the transdermal amount of oxaprozin in different Azone concentrations liniments. RESULTS: Comparison of oxaprozin liniment having no Azone with the liniments containing different Azone concentrations of 0.5%��1.0%��2.0%��3.0% showed a remarkable difference(P<0.05)or very remarkable difference(P<0.O1).Improving the transdermal amount of oxaprozin was not related to the concentrations of Azone. CONCLUSION: All different concentrations of Azone could improve the transdermal amount of oxaprozin, especially, oxaprozin liniment containing 0.5% Azone.

Keywords�� Azone, oxaprozin, transdermal absorption

�ո��: 1996-04-30;

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.�¹�ܳ(��)׿(��)ͪ�Կ�(��)��(��)��͸Ƥ��õ��о�[J] �й�ҩѧ��־, 1997,V32(01): 25-27

.Azone affecting the transdermal absorption of oxaprozin[J] Chinese Pharmaceutical Journal, 1997,V32(01): 25-27

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