摘要
目的对来源于红树林的海洋真菌Cladosporium cladosporioides的发酵产物进行化学成分研究。方法采用溶剂提取、硅胶柱色谱及半制备HPLC等分离方法对真菌菌丝体进行分离纯化,通过波谱学方法进行结构鉴定。结果分离得到10个化合物,分别为二十四烷酸(1)、麦角甾-5,7,22-三烯-3β-醇(2)、24-亚甲基羊毛脂甾-8-烯-3β-醇(3)、1-(硬脂酸)-2-(亚油酸)-3-油酸甘油酯(4)、1,2,3-三亚油酸甘油酯(5)、1,3-二油酸甘油酯(6)、肉桂酸(7)、苯丙酸(8)、β-谷甾醇(9)、丁二酸单乙酯(10)。结论化合物1～10均为首次从该菌种分离得到。
Abstract
OBJECTIVE To investigate the chemical constituents of marine fungus Cladosporium cladosporioides from mangrove. METHODS The components were isolated by means of solvent extraction,silica gel column chromatography and semi-preparative HPLC. The structures were elucidated by spectral analysis. RESULTS Ten compounds were isolated and identified as tetracosanoic acid (1) ,ergosta-5 ,7,22-trien-3β-ol (2) ,eburicol (3) ,1-(octadecanoyl)-2-(cis,cis)-9,12-octadecadienoyl-3-(cis)-9-octadecenoyl-glycerol (4),1,2,3-trilinolein (5),glycerol 1,3-bisoleate (6),cinnamic acid (7),3-phenyl-propionic acid (8),β-sitosterol (9),succinic acid monoethyl ester (10). CONCLUSION These compounds were obtained from the fungus for the first time.
关键词
Cladosporiumcladosporioides /
海洋真菌 /
次生代谢产物
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Key words
Cladosporium cladosporioides /
marine fungus /
secondary metabolites
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邹建华;戴均贵.
海洋真菌Cladosporium cladosporioides化学成分研究[J]. 中国药学杂志, 2009, 44(06): 418-421
ZOU Jin-hu;DI Jun-gui.
Study on Chemical Constituents in Marine Fungus of Cladosporium cladosporioides[J]. Chinese Pharmaceutical Journal, 2009, 44(06): 418-421
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脚注
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基金
国家自然科学基金资助项目(20602042)
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