目的研制葛根素温度敏感凝胶剂。方法建立UV测定制剂的含量及体外释药量,采用搅拌子法测定相转变温度并测定黏度,从而确定处方。采用桨法进行处方的体外释药实验。结果确定20%的泊洛沙姆407和10%的泊洛沙姆188作为葛根素温度敏感凝胶的基质。凝胶体外释放符合Higuchi方程。结论葛根素温度敏感凝胶达到了滴入眼内形成凝胶并且延迟释放的目的。

OBJECTIVE To study puerarin thermosensitive gel.METHODS The content and the release amount of puerarin from the gel base were determined by UV.The gel temperature of the various concentration polymer solution was studied using stirring method and the viscosity of gel was monitored under different temperatures.Release behaviors of PUE from the gel base were exploredin a dissolution apparatus under stirring conditions.RESULTS 20% Poloxmar407 and 10% poloxmar 188 were suitable concentration for the formulation of PUE thermosensitive gel.The formulation release behavior in vitro followed Higuchi equation.CONCLUSION The puerarin thermosensitive gel forms gel in eye and has longer release time than that of eye drops.