Abstract��
OBJECTIVE To study puerarin thermosensitive gel.METHODS The content and the release amount of puerarin from the gel base were determined by UV.The gel temperature of the various concentration polymer solution was studied using stirring method and the viscosity of gel was monitored under different temperatures.Release behaviors of PUE from the gel base were exploredin a dissolution apparatus under stirring conditions.RESULTS 20% Poloxmar407 and 10% poloxmar 188 were suitable concentration for the formulation of PUE thermosensitive gel.The formulation release behavior in vitro followed Higuchi equation.CONCLUSION The puerarin thermosensitive gel forms gel in eye and has longer release time than that of eye drops.
SONG Cheng-jun,
LIU Zhi-dong,
TIAN Lei etc
.Study on Preparation and Release in Vitro of Puerarin Thermosensitive Gel [J] Chinese Pharmaceutical Journal, 2008,V43(15): 1157-1161
��
[1]
ZHANG Y L��LIANG J Y.Research progress on puerarin[J] . Strait Pharm J��2005��17��1����2-5.
[2]
LU B. New Techniques and New Dosage Forms of Drugs��ҩ���¼������¼�����[M] .Beijing��People��s Medical Publishing House��1998��422-431.
[3]
HELENE H��MATTIAS P��KATARINA E. Evaluation of mucoadhesion for two polyelectrolyte gels in simulated physiological conditions using a rheological method[J] .Eur J Pharm Sci��2000��9��3����301-309.
[4]
LU B. New Techniques and New Dosage Forms of Drugs��ҩ���¼������¼�����[M] .Beijing��People��s Medical Publishing House��1998��416.
2008, Vol. 43 
