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�й�ҩѧ��־ 2008, Vol. 43 Issue (10) :746-750    DOI:
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WEI Fang��WEI Wei
Institute of Clinical Pharmacology��Anhui Medical University��Anhui Key Lab of Antiinflammatory and Immunopharmacology��Anhui Center of Engineering for Antiinflammatory and Immune Drugs��Anhui Key Lab of Research and Development for Chinese Medicine��Hefei 230032��China

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ժҪ Ŀ���о����ζ���(SQDG)�Դ���ԭ�Թؽ���(CIA)����������,������̽�������û��ơ������ڽ��������ͽ�ԭ�յ��Ĵ���ؽ���ģ�ͻ�����,ͨ�������צ�ݻ����ؽ������ֺ�δ���ײ�������צѹʹ�۲�����۹ؽ���֢�ķ������;�۲�����ָ����Ƣ��ָ���ı仯;MTT�����T��Bϸ����ֳ��Ӧ;С���ܰ�ϸ����ֳ�����IL-1��IL-2����;ELISA�����Ѫ�п����ͽ�ԭ���塣����������ߺ��14�������צ����,�̷�����֢�߷����ڵ�22��,��֢�ڵ�26���ʼ���ᡣSQDG(21.25,42.5,85mg��kg-1)����������(TGP,50mg��kg-1)������������(ASTs,7mg��kg-1)ig��ҩ�ܲ�ͬ�̶ȵļ���CIA����Ĺؽ���֢,ʹ���ߵĴ�������ָ����Ƣ��ָ������;��һ���о�����,SQDG��TGP��ASTs��ʹCIA�������ߵ�ConA�յ���Tϸ����ֳ��LPS�յ���Bϸ����ֳ��Ӧ�½�;�µ����ߵ�Ƣϸ��IL-2ˮƽ�����ߵĸ�ǻ����ϸ��IL-1ˮƽ;��ʹCIA����Ѫ�������ߵĿ�C�����½�������SQDG�Դ���CIA���нϺõ���������,�������������쳣���߹����йء�
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Abstract�� OBJECTIVE To study the treatment effects of Shaoqiduogan(SQDG) on collagen-induced arthritis(CIA) in rats.METHODS Chicken type �� collagen was used to induce CIA in rats.The volume of uninduced-inflammation paws of rats,arthritic scores and tenderness of uninduced-inflammation paws were determined for evaluating occurrence status of arthritis.The diversity of thymus index and spleens index were observed.T and B cells proliferation was determined by 3-(4,5-dimethylthiazal-2yl) 2,5-diphenyltetrazoli-umbromide(MTT) assay,and interleukin-1(IL-1) activity was measured by thymocyte proliferation assay.Anti-�� collagen antibody in blood was detected by ELISA assay.RESULTS Rats occurrenced red swelling of the paws on d 14 after immunity,crest-time of secondary inflammation was on d 22,and the inflammation began abatement on d 26.SQDG(21.25,42.5,85 mg��kg-1),TGP(50 mg��kg-1),ASTs(7 mg��kg-1)ig alleviated the inflammation of joint at different degree and decreased thymus index,spleens index of CIA rats.The further study demonstrated that SQDG,TGP and ASTs suppressed the excessive T and B cell proliferation and over-production of IL-1 and interleukin-2(IL-2),and decreased the elevated anti-�� collagen antibody in blood.CONCLUSION SQDG has a treating effect on CIA in rats,and the mechanism of treatment maybe concern with its regulation on the abnormal immune responses in CIA rats.
Keywords�� Shaoqiduogan,   collagen-induced arthritis,   inflammation,   immunity      
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.���ζ��նԴ���ԭ�Թؽ��׵���������[J]  �й�ҩѧ��־, 2008,V43(10): 746-750
.Effects of Shaoqiduogan on Rats with Collagen-Induced Arthritis [J]  Chinese Pharmaceutical Journal, 2008,V43(10): 746-750
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