摘要
目的 探讨黄芪多糖（APS改善胰岛素敏感性的作用机制。方法 以高脂饮食诱导的肥胖大鼠为观察对象，吡格列酮为阳性对照，以胰岛素钳夹实验评价胰岛素敏感性，观察黄芪多糖（APS对葡萄糖输注率（SSGIR及血浆代谢指标、抵抗素（resistin和脂联素（adiponectin，APN的影响。结果 和正常对照组（NC组比较，高脂对照组（HFC组、吡格列酮组（Pio组、黄芪多糖组（APS组的SSGIR、APN降低，而空腹胰岛素（FINS、游离脂肪酸（FFA、抵抗素升高，差异有显著意义(P<0.05；和HFC组比较，Pio组、APS组的SSGIR、APN升高，而FINS、FFA、抵抗素减低，差异有显著意义(P<0.05。肥胖大鼠FFA、FINS、抵抗素、APN和SSGIR之间进行线性相关分析，上述指标两两之间均存在显著的相关性(P<0.05。结论 高脂饲料诱导的肥胖大鼠体内存在胰岛素抵抗，血浆FFA、抵抗素水平升高而APN水平降低；APS可以改善其胰岛素敏感性，这种作用和降低血浆FFA、抵抗素及升高APN有关。
Abstract
OBJECTIVE To study the effect of astragalus polysaccharides on insulin sensitivity and its mechanism.METHODS Insulin clamp experiment was used to evaluate the insulin sensitivity of high fat-diet-induced insulin resistance rats. The glucose infusion rate(GFR， metabolic indicator，plasma resistin and adiponectin were compared among astragalus polysaccharides group(APS group and others control groups. Control groups included normol control group(NC， high fat-diet-induced control group(HFC and pioglitazone group(pio group. Pioglitazone group was positive control.RESULTS Compared with NC，GIR and adiponectin were decreased in HFC，APS group and pio group， while fast insulin， free fat acid and resistin were increased. The difference was significant(P<0.05. Compared with HFC， GIR and adiponectin were significantly increased in APS group and pio group， while fast insulin，free fat acid and resistin were significantly decreased(P<0.05. The relationships among FFA， FINS， resistin， APN and SSGIR were analyzed and significant relationship was found (P<0.05. CONCLUSION High fat-diet induced rats insulin resistance，the increase of plasma FFA and resistin， and the decrease of APN. APS can increase insulin sensitivity in fatty rats， raise plasma APN and reduce resistin in this process.
关键词
黄芪多糖 /
钳夹实验 /
胰岛素抵抗 /
抵抗素 /
脂联素
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Key words
astragalus polysaccharides /
clamp technique /
insulin resistance /
resistin /
adiponectin
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王涛 魏学娟 翁孝刚 陈雪辉 曹萌.
黄芪多糖对肥胖大鼠胰岛素敏感性的影响[J]. 中国药学杂志, 2011, 46(3): 185-188
WNG To;WEI Xue-jun;WENG Xio-gng;CHEN Xue-hui;CO Meng.
Effects of Astragalus Polysaccharides on the Insulin Sensitivity in the Fat Rats[J]. Chinese Pharmaceutical Journal, 2011, 46(3): 185-188
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