目的 阐述端粒酶的结构、功能以及端粒酶与肝纤维化的关系,探讨肝纤维化过程中肝细胞与肝星状细胞内端粒酶活性的变化,为肝纤维化的防治提供新的药物作用靶点。方法 依据近年国内外的相关文献对端粒酶相关系统进行综述。结果 在肝纤维化形成过程中,肝细胞中端粒是缩短的,从端粒酶的经典与非经典的生理功能角度上增加端粒酶的活性可使肝细胞获得再生的能力;肝星状细胞中的端粒是延长的,从端粒酶的经典生理功能角度上减弱端粒酶的活性可使肝星状细胞凋亡。 结论 端粒酶有望成为治疗肝纤维化的一个潜在的药物靶点。
关键词
端粒 /
端粒酶 /
肝纤维化
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参考文献
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脚注
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