微透析技术在脑部喹诺酮类药物药代动力学中的研究进展

秦升 袁少华 华翔 黄怡

中国药学杂志 ›› 2011, Vol. 46 ›› Issue (14) : 1089-1091.

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PDF(494 KB)
中国药学杂志 ›› 2011, Vol. 46 ›› Issue (14) : 1089-1091.
综述

微透析技术在脑部喹诺酮类药物药代动力学中的研究进展

  • 秦升1,袁少华1,华翔1,黄怡2*
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文章历史 +

摘要

目的 分析微透析技术在药物代谢动力学研究中的应用现状,探索不同给药途径下,喹诺酮类药物在中枢内的药动学差异。方法 检索国内外相关资料,归纳总结利用微透析技术研究外源性化学物质,特别是抗感染药物药动学的优点,分析喹诺酮类药物在中枢神经系统的应用及药动学研究现状。结果 通过微透析取样,可获得异源物质的动力学数据,且不会引起实验动物明显的生理变化。喹诺酮类药物具有良好的血脑屏障穿透力和抗菌活性,适用于中枢神经系统敏感菌株感染的治疗。结论 利用微透析技术,比较口服和静脉给药途径下,喹诺酮类药物在中枢内的药动学差异,将会给临床给药途径的选择提供可靠的理论依据。

关键词

药动学 / 喹诺酮类 / 中枢神经系统 / 微透析

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秦升 袁少华 华翔 黄怡. 微透析技术在脑部喹诺酮类药物药代动力学中的研究进展[J]. 中国药学杂志, 2011, 46(14): 1089-1091

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