摘要
目的 研究玉簪［Hosta plantaginea （Lam.）Aschers］花的化学成分。方法 利用溶剂法进行提取和萃取分部，采用硅胶柱色谱、Sephadex LH-20柱色谱进行分离，利用理化鉴别及现代波谱分析技术鉴定化合物的结构。结果 从中分离鉴定了6个甾体化合物，分别为(25R)-5α-螺旋甾烷-2α，3β-二醇（支脱皂苷元）（1）， (25R)- 2α，3β-二醇-5α-螺旋甾烷-12-酮（曼诺皂苷元）（2），胡萝卜苷（3），支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基(1→2)-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷}（4），支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基(1→2)-O-［β-D-吡喃木糖基(1→3)］-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷}（5）和支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基-(1→2)-O-［O-α-L-呋喃鼠李糖基-(1→4)-β-D-吡喃木糖基(1→3)］-O-β-D-吡喃葡萄糖-(1→4)-β-D-吡喃半乳糖苷}（6）。结论 6个化合物均为首次从该植物中得到。
Abstract
OBJECTIVE To investigate the chemical constituents of the flowers of Hosta plantaginea (Lam.) Aschers. METHODS The chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatography and elucidated on the basis of physiochemical properties and spectral analysis. RESULTS Six steroidal compounds were isolated from the flower of H. plantaginea and identified as (25R)-5α-spirostan-2α，3β-diol (gitogenin) (1)， (25R)-2α，3β-diol-5α-spirostan-12-one (manogenin) (2)， daucosterol (3)， gitogenin-3-O-{-O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranosyl-(l→4)-β-D-galactopyranoside} (4)， gitogenin-3-O-{O-β-D-glucopyranosyl-(1→2)-O-［β-D-xylopyranosyl-(1→3)］-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside} (5)， gitogenin-3-O-{O-β-D-glucopyranosyl-(1→2)-O-［O-α-L-rhamnopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)］-0-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside}(6). CONCLUSION All of the compounds were isolated from H. plantaginea for the first time.
关键词
玉簪花 /
化学成分 /
甾体
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Key words
Hosta plantaginea /
chemical constituents /
steroids
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张金花 解红霞 薛培凤 张宏桂 刘心钰 白吉木色 .
蒙药玉簪花中的甾体化合物[J]. 中国药学杂志, 2010, 45(5): 335-338
ZHNG Jin-hu;XIE Hong-xi;XUE Pei-feng;ZHNG Hong-gui;LIU Xin-yu;I Ji-mu-se.
Steroidal Constituents from Flowers of a Mongolia Herb， Hosta plantaginea (Lam.) Ascherson [J]. Chinese Pharmaceutical Journal, 2010, 45(5): 335-338
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参考文献
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