抗癌药物喜树碱类衍生物的研究进展

代鲁平 宋春霞 邵先祥 张耀

中国药学杂志 ›› 2010, Vol. 45 ›› Issue (23) : 1813-1815.

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中国药学杂志 ›› 2010, Vol. 45 ›› Issue (23) : 1813-1815.
综 述

抗癌药物喜树碱类衍生物的研究进展

  • 代鲁平,宋春霞*,邵先祥,张耀
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摘要

目的 综述喜树碱类衍生物的抗癌药理机制及开发应用方面的研究进展。方法 以国内外研究文献为基础,对文献资料进行分析和总结。结果 喜树碱类衍生物是拓扑异构酶Ⅰ抑制剂,抗癌药物研究中的热点,已广泛应用于临床。本文综述了5种喜树碱类衍生物药物的开发应用最新进展。结论 喜树碱类衍生物的抗癌药理作用机制尚未完全阐明,随着对其构效关系及作用机制的不断研究,将会有更多更有效的喜树碱类衍生物成为抗癌的一线药物。

关键词

抗肿瘤药物 / 喜树碱 / 机制 / 拓扑异构酶

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代鲁平 宋春霞 邵先祥 张耀. 抗癌药物喜树碱类衍生物的研究进展[J]. 中国药学杂志, 2010, 45(23): 1813-1815

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