[1] CHENG L, ZHOU X J. Review on anticancer mechanism of some plant alkaloids [J]. Chin Tradit Herb Drugs (中草药), 2004, 35(2): 216-221. [2] LI C J, GU Y, HAN Y X, et al. Research progress in camptothecin and its analogues [J]. Chin J Med Chem (中国药物化学杂志), 2003, 13(5): 306-310. [3] MENG F H, GONG L Y, TONG X. Anti-tumor drug-research development of camptothecin derivatives [J]. Chem Life (生命的化学), 2002, 22(3): 265-267. [4] JIANG Q, WANG H X. Research and Application of Camptothecins [J]. Prog Pharm Sci (药学进展), 2007, 31(9): 408-412. [5] PATEL S H, AJLOUNI M, CHAPMAN R, et al. A prospective phase Ⅱ study of induction carboplatin and vinorelbine followed by concomitant topotecan and accelerated radiotherapy (ART) in locally advanced non- small cell lung cancer (NSCLC) [J]. J Thorac Oncol, 2007, 2(9): 831-837. [6] ZHANG X Z, LI J, GONG H J, et al. Effects of topotecan on radiosensitization of esophageal carcinoma cell line Eca-109 and its mechanism [J]. J Mod Oncol(现代肿瘤医学), 2009, 17(10): 1850-1853. [7] XIE B F, PAN B L. Topotecan in combination with cisplatin in the treatment of head and neck squamous cell carcinoma [J]. Chongqing Med (重庆医学), 2008, 37(17): 1986-1987. [8] CHENG B Z, XIE B, WANG P, et al. Topotecan in combination with carboplatin in the treatment of recurrent small cell lung cancer [J]. J Mod Oncol(现代肿瘤医学), 2010, 18(4): 718-720. [9] O′REILLY E, DONEHOWER R C, ROWINSKY E K, et al. A phase II trial of topotecan in patients with previously untreated pancreatic cancer [J]. Anti-Cancer Drugs, 1996, 7(4): 410-414. [10] ROWINSKY E K, BAKER S D, BRUKS K, et al. High-dose topotecan with granulocyte-colony stimulating factor in fluoropyrimidine-refractory colorectal cancer: a phase II and pharmacodynamic study [J]. Ann Oncol, 1998, 9(2): 173-180. [11] PAN X D, WANG C Y. Current status of camptothecin derivatives as natural antitumor agents [J]. Acta Pharm Sin (药学学报), 2003, 38(9): 715-720. [12] ZHANG Y N, WEI M J, SUN M J. The correlation between the inhibiting effects of irinotecan on colorectal cancer cell proliferation and ATP -sensitive potassium channel [J]. J China Med Univ(中国医科大学学报), 2010, 39(1): 10-13. [13] HUANG Q, CHEN H, XU X H, et al. Treatment of irinotecan for recurring advanced ovarian cancer [J]. Aerospace Med (航空航天医药), 2010, 21(2): 140-141. [14] ZHAO Y J, CAO Y. Clinical efficacy of irinotecan for extensive small-cell lung cancer [J]. Eval Anal Drug-Use Hosp China (中国医院用药评价与分析), 2009, 9(2): 136-138. [15] ZHU L M. Research progress in First-line Chemotherapy for Advanced Pancreatic Cancer [J]. J Oncol(肿瘤学杂志), 2010, 16(5): 404-408. [16] TAYLOR J, AMANZE A, DI FEDERICO E, et al. Irinotecan Use During Pregnancy [J]. Obstet Gynecol, 2009, 114(2): 451-452. [17] WANG L Y. Antineoplastic Iirinotecan Research Progress [J]. Foreign Med Sci (Sec Pharm) (国外医学:药学分册), 2004, 31(1): 7-11. [18] HONG M H, PEI Y Y. Hydroxycamptothecin and formulations [J]. Chin J Clin Pharm (中国临床药学杂志), 2008, 17(4): 255-258. [19] LAI R Y, LI X B, XU C J, et al. Hydroxycamptothecin on human pancreatic cancer cell growth inhibition of PANC-1 [J]. Lishizhen Med Mater Med Res (时珍国医国药), 2009, 20(8): 2039-2040. [20] JIN G H, CHEN S, YANG L, et al. Hydroxycamptothecin induced human prostate cancer Line PC-3m cell apoptosis [J]. Chin J Lab Diagn (中国实验诊断学), 2010, 14(1): 12-13. [21] XIAO K F. Research progress of camptothecin [J]. Lishizhen Med Mater Med Res (时珍国医国药), 2004, 15(11): 787-789. [22] NING S H, LI G F, HUANG Y S, et al. Oxaliplatin combined with camptothecin treatment of elderly cancer 32 cases [J]. Chin J Gerontol (中国老年学杂志), 2010, 30(11): 1572-1574. [23] LI ZH Y, GUO Y. Camptothecin derivatives——a kind of antitumor agents [J]. Chin New Drugs J(中国新药杂志), 2000, 9(9): 598-601. [24] VOKES E E, ANSARI R H, MASTERS G A, et al. A phase II study of 9-aminocamptothecin in advanced non-small-cell lung cancer [J]. Ann Oncol, 1998, 9(10): 1085-1090. [25] HOCHSTER H, PLIMACK E R, RUNOWICZ C D, et al. Biweekly 72-h 9-aminocamptothecin infusion as second-line therapy for ovarian cancinoma: Phase II study of the new york gynecologic oncology group and the eastern cooperative oncology group [J]. J Clin Oncol, 2004, 22(1), 120-126. [26] YANG H. The anti-tumor new drug:9-nitrocamptothecin [J]. Int J Surg(国际外科学杂志), 2008, 35(6): 396-398. [27] ZHANG W, WANG J W, CUI C X, et al. PhaseⅠhuman tolerability trial of rubitecan tablets [J]. Chin J New Drugs (中国新药杂志), 2010, 19(8): 676-680. [28] MENG X Y, LIU Z Y. Research Progress of Rubitecan [J]. Her Med (医药导报), 2008, 27(2): 204-207. [29] XIAO F, LUO Y, LV W, et al. A novel synthesis of chimmitecan [J]. Chin J Org Chem (有机化学), 2010, 30(2): 311-313. [30] HUANG M, GAO H, CHEN Y, et al. Chimmitecan, a novel 9-substituted camptothecin,with improved anticancer pharmacologic profiles in vitro and in vivo [J]. Clin Cancer Res, 2007, 13(4): 1298-1307.