目的 考察在葡萄糖溶液中，吡柔比星和胰岛素配伍的稳定性。方法 观察室温、避光、6 h内，吡柔比星-胰岛素-5%葡萄糖配伍液的外观、pH变化，观察配伍液中不溶性微粒的变化（《中国药典》2010年版附录），采用高效液相色谱法考察配伍液中吡柔比星、胰岛素含量的变化。结果 配伍液在6 h内无浑浊、沉淀、气体产生，颜色、pH、不溶性微粒数等无明显变化，吡柔比星、胰岛素含量无明显变化。结论 在实验条件下，吡柔比星、胰岛素在5%的葡萄糖注射液中配伍稳定。

OBJECTIVES To observe the compatibility of insulin and pirarubicin for injection. METHODS The changes of appearance，particles and pH were observed under ambient temperature and kept in dark place in 5% glucose injection.The concentrations of the insulin and pirarubicin were determined by HPLC. RESULTS There was no evident changes in appearance， no color， gas， preci pitation or turbid generated. No changes were obtained in opacity，pH and the content of insulin and pirarubicin within 24 h. CONCLUSION Insulin injection mixing with pirarubicin for injectionin in 5% glucose was stable within 24 h.