大蒜油静脉注射乳剂大鼠体内组织分布的研究

何进 郭涛 孙学惠 周闺臣

中国药学杂志 ›› 2010, Vol. 45 ›› Issue (20) : 1567-1571.

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中国药学杂志 ›› 2010, Vol. 45 ›› Issue (20) : 1567-1571.
论 著

大蒜油静脉注射乳剂大鼠体内组织分布的研究

  • 何进1,郭涛1*,孙学惠1,周闺臣2
作者信息 +

Studies on the Tissue Distribution of Intravenous Emulsion of Garlic Oil in Rats

  • HE Jin1,GUO Tao1*, SUN Xue-hui 1,ZHOU Gui-chen2
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摘要

目的 探讨大蒜油静脉注射乳剂(GO-E)在大鼠体内的组织分布。方法 36只健康大鼠,单剂量颈静脉注射GO-E或大蒜油注射液(GO-INJ),并于给药后5,30,60 min采集大鼠心、肝、脾、肺、肾、脑组织,用气相电子捕获法(GC-ECD)分别测定大蒜油指标性成分二烯丙基二硫化合物(DADS)和二烯丙基三硫化合物(DATS)在各组织中的浓度;以大蒜油注射液(GO-INJ)为对照药物,对GO-E在大鼠心、肝、脾、肺、肾、脑的分布进行比较。结果 大鼠颈静脉给药后,GO-E和GO-INJ在各组织中的分布主要以DADS为主。给药5 min时,二种制剂主要分布在肺、肾、脑、心组织,且在肝脏中GO-E的分布高于GO-INJ。30 min时,二种制剂DADS和DATS总浓度在各组织中均有降低。60 min时,GO-E中的DADS和DATS在各组织中总浓度仍较高,而GO-INJ在有些组织中已检测不到DADS或DATS了。结论 GO-E在各组织中驻留时间比GO-INJ长,提示GO-E具有一定的缓释作用,而被动靶向作用不明显。

Abstract

OBJECTIVE To study the tissue distribution of intravenous emulsion of garlic oil(GO-E) in rats. METHODS A single dose of GO-E or Go-INJ was administered to 36 healthy rats via the jugular vein. The tissues of heart ,liver,spleen,lung,kidney and brain were acquired at 5, 30 or 60 min after administration. GC-ECD was used to determine the concentration of DADS or DATS in the tissues of rats. Controlled by garlic oil injection(GO-INJ) ,the comparative stadies on the distributions of the tissues in the heart, liver, spleen, lung,kidney,brain were performed. RESULTS The distribution of DADS had an advangtage in rat tissues after the administration of two formulations. DADS and DATS of two formulations were distributed in lung,kidney,brain and heart at 5min after administration. The distribution of two components of GO-E in liver was more than that of GO-INJ. The total concentration of DADS and DATS of two formulations were gradually reduced in tissues at 30 min after administration. The total concentration of DADS and DATS of GO-E had an advangtage over that of GO-INJ at 60 min after administration. CONCLUSION Compared with GO-INJ, the residence time of GO-E was longer in tissues. GO-E possess an effect of sustained release to some extent. The effect of passive target is not obvious.

关键词

二烯丙基二硫化合物 / 二烯丙基三硫化合物 / 组织分布 / GC-ECD

Key words

DADS / DATS / Tissue distribution / GC-ECD

引用本文

导出引用
何进 郭涛 孙学惠 周闺臣. 大蒜油静脉注射乳剂大鼠体内组织分布的研究[J]. 中国药学杂志, 2010, 45(20): 1567-1571
HE Jin;GUO To;SUN Xue-hui;ZHOU Gui-chen. Studies on the Tissue Distribution of Intravenous Emulsion of Garlic Oil in Rats[J]. Chinese Pharmaceutical Journal, 2010, 45(20): 1567-1571

参考文献


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