摘要
目的 研究紫金砂的化学成分。方法 药材采用体积分数80％乙醇提取，氯仿萃取，利用硅胶柱，RP-18反相柱，Sephadex LH-20凝胶柱分离纯化，并根据理化性质和波谱数据进行结构鉴定。结果 分离鉴定13个化合物，分别为异欧前胡素（1）、水合氧化前胡素内酯（2）、拐芹色原酮（3）、佛手柑内酯（4）、欧前胡素（5）、ledebouriellol（6）、二氢欧山芹素（7）、isopimpinellin（8）、osthol（9）、3′(R)-+-亥茅酚（10）、oxypeucedanin ethanolate（11）、β-谷甾醇（12）、豆甾醇（13）。结论 化合物6~11为首次从紫金砂中分离得到，其中化合物6、11为首次从当归属植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of Angelica polymorpha Maxim. METHODS The chloroform-soluble fraction of alcohol-extract was isolated and purified by column chromatography on silicagel，RP-18 and Sephadex LH-20 column. All compounds were identified on the basis of spectral analysis and physico-chemical characters. RESULTS Thirteen compounds were isolated and identified as isoimperatorin (1)，aviprin (2)，angeliticin A (3)，bergapten (4)，imperatorin (5)，ledebouriellol (6)，columbianadin (7)，isopimpinellin (8) ，osthol (9) ，3′(R)-+-hamaudol (10) ，oxypeucedanin ethanolate (11) ，β-sitosterol (12) and stiamasterol (13). CONCLUSION Compounds 6-11 were isolated from this plant for the first time. Compound 6 and 11 were isolated from this genus for the first time.
关键词
紫金砂 /
当归属 /
化学成分
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Key words
Angelica polymorpha Maxim /
Angelica /
chemical constituents
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杨郁 于能江 张杨 任凤霞 张爱军 赵毅民.
紫金砂化学成分研究[J]. 中国药学杂志, 2010, 45(17): 1320-1322
YNG Yu;YU Neng-jing;ZHNG Yng;REN Feng-xi;ZHNG i-jun;ZHO Yi-min.
Studies on Chemical Constituents of Angelica polymorpha Maxim.[J]. Chinese Pharmaceutical Journal, 2010, 45(17): 1320-1322
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参考文献
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