目的 研究更昔洛韦药物树脂交换动力学与热力学。 方法 用动边界模型描述了更昔洛韦交换过程的动力学；用热力学参数描述了更昔洛韦交换过程的热力学。 结果 确定更昔洛韦交换行为的速度控制步骤为颗粒扩散，更昔洛韦交换过程的 表观活化能为 - 27.95 kJ·mol -1 , 交换反应的自由能变化△ <> G >0 ，焓变△ <> H 0 m <0, 熵变△ <> S <0 。 结论 通过对更昔洛韦与树脂的动力学与热力学研究，为更昔洛韦药物树脂释药系统提供理论依据。
Abstract
OBJECTIVE To study the exchange kinetics and thermodynamics behavior of ganciclovir-resin complexes. METHODS Moving Boundary Model was applied to describe the kinetics of exchange process. Thermodynamic parameters were used to describe the thermodynamic behavior of exchange process. RESULTS The dominant procedure was ion diffusion through particles. The exchange activation energies were -27.95 KJ·mol-1. The △G value was greater than zero. The reaction enthalpy △H0m was less than zero. The reaction entropy △S was also less than zero. CONCLUSION The exchange kinetics and thermodynamics behavior of ganciclovir-resin complexes could supply the theory for the ion exchange resin-ganciclovir drug delivery system.
关键词
更昔洛韦 /
离子交换树脂 /
动力学 /
热力学
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Key words
ganciclovir /
ion exchange resin /
kinetics /
thermodynamics
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参考文献
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（ 收稿日期 ： 2009-01-08 ）
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