摘要
目的研究马蔺(Iris lactea Pall.var.chinensis)的化学成分。方法采用反复硅胶柱色谱法、Sephadex HL-20柱色谱法及重结晶等进行分离纯化,并通过理化常数测定和光谱分析鉴定了其化学结构。结果从马蔺体积分数70%乙醇提取物中分离得到10个化合物,并鉴定其结构为:5,7,4′-三羟基-6-甲氧基黄酮(hispidulin,1)、5,4′-二羟基-6、7-亚甲二氧基黄酮(kanzakiflavone-2,2),5-羟基-7、4′-二甲氧基黄酮-6-C-β-D-葡萄糖(embigenin,3),5-羟基-7、4′-二甲氧基黄酮-6-C-β-D-葡萄糖-2-O-L-鼠李糖(embinin,4),5、7-二羟基-苯并呋喃色酮(ayamenin B,5),1、3、6、7-四羟基(口山)酮-2-C-β-D-葡萄糖(mangiferin,6),胡萝卜苷(7),β谷甾醇(8)以及papuline(9)、3-苯基乳酸(α-hydroxybenzenepropanoic acid,10)。结论其中化合物1～3,5,7～10均为在该植物中首次分得,化合物9、10为本属植物中首次发现。
Abstract
OBJECTIVE To study the chemical constituents of the leaves of Iris lactea Pall.var.Chi-nensis (Fisch.) koidz.. METHODS The raw material was extracted with 70% alcohol,isolated by column chromatography on silica gel,and purified by Sephadex HL-20 and recrystallization. RESULTS Ten compounds were isolated as 5,7,4′-trihydroxy-6-methoxyflavone(hispidulin,1),5,4′-dihydroxy-6,7-methylenedioxyflavone (kanzakiflavone-2,2),6-C-glucosylapigenin 7,4′-dimethyl ether (embigenin , 3) , embinin (4) , ayamenin B(5) , mangiferin(6) , daucosterol (7) , β-sitosterol (8), papuline (9) and α-hydroxybenzenepropanoic acid (10). CONCLUSION Compound 1-3,5,7-10 were isolated from this plant for the first time,Compound 9 and 10 were isolated from this genus for the first time.
关键词
马蔺 /
鸢尾科 /
化学成分
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Key words
Iris lactea var.chinensis /
Iridaceae /
chemical constituents
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沈文娟;秦民坚;邓雪阳;束盼;吴刚 .
马蔺叶的化学成分[J]. 中国药学杂志, 2009, 44(04): 249-251
SHEN Wen-jun;QIN Min-jin;DENG Xue-yng;SHU Pn;WU Gng;.
Chemical Constituents of Leaves of Iris lactea Pall.var. chinensis[J]. Chinese Pharmaceutical Journal, 2009, 44(04): 249-251
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参考文献
[1] XIA G C，ZANG J Y，LU X M，et al. Resource utilization and herbal study of “MALINZI” (Iris lactea Pall. Var. chinensis ) [J]. Acta Pharm Sin(药学学报)，1985，20（4）：316-319.
[2] SHEICHENKO V I，BLINOVA K F. Acylated C-glycosides of Iris lactea [J]. Khim Prir Soedin，1984，(5)：589-595.
[3] BLINOVA K F. Swertiajaponin from Iris lactea [J]. Khim Prir Soedin，1987，(2)：304-305.
[4] LIU Y L，MABRY T J. Flavonoids from Artemisia frigida[J]. Phytochemistry，1981，20：1389-1395.
[5] MUNEHISA A，HARUHISA K，NAOKATA M. Studies on constituents of genus Iris. Ⅷ The constituents of iris unguicularis Poir.(2) [J]. Chem Pharm Bull，1976，24 (7)：1609-1612.
[6] MUNEHISA A，NAOKATA M. Studies on constituents of Iris florentina L. and the consti-tuents of the petals of Iris japonica Thunb. [J]. Yakugaku Zasshi，1973，93 (12)：1655-1659.
[7] FUJINORI H，SATOSHI T，JUNYA M. Isoflavones produced by Iris pseudacorus leaves treated with cupric chloride [J]. Phytochemistry，1991，30 (1)：157-163.
[8] MASAO FUJITA, TAKAO INOUE. Studies on the constituents of Iris florentina L.Ⅱ. C-Glucosides of xanthones and flavones from the leaves [J]. Chem Pharm Bull，1982，30(7)：2342-2348.
[9] ANTONIO EVIDENTE, NICOLA S, IACOBELLIS, et al. Isolation of β-phenyllactic acid related compounds from pseudomonas syringae [J]. Phytochemistry，1990，29 (5)：1491-1497.
[10] POUCHERT C J，BEHNKE J. Aldrich Library of 13C and 1H FT NMR Spectra [M]. 2996 A，1024C. New York：Aldrich Chemical Company Inc.1992 .
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脚注
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基金
国家自然科学基金资助项目(30170103)
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