摘要
目的研究经典方芍药甘草汤的配伍合理性。方法在建立芍药甘草体内成分指纹图谱分析方法的基础上,运用药动学方法,比较芍药甘草汤和芍药单煎液灌胃给药后不同时间的大鼠血清中归属于芍药的各特征化学成分含量的变化,并对药动学参数进行方差分析。结果与芍药单煎液比较,芍药甘草汤的AUC显著增加,ρmax大多极其显著增加,显示出良好的吸收。结论从药动学角度揭示了芍药甘草汤配伍的科学性和合理性。
Abstract
OBJECTIVE To study compatibility rationality of Shaoyao-gancao decoction.METHODS Rats were orally administered with Shaoyao-gancao decoction and Shaoyao decoction.Blood samples at different times were collected,then were analysed by HPLC fingerprints technology.The pharmacokinetic parameters of characteristic peaks were analyzed by SPSS13.0 software.RESULTS The absorption of these compounds in Shaoyao decoction were increased by coadministration with Gancao.The pharmacokinetic parameters such as AUC,ρmax were increased.CONCLUSION The compatibility connotation of Shaoyao-gancao decoction was revealed by an the angle of pharmacokinetics.The absorptions of characteristic peaks from Shaoyao were increased distinguished after co-administration with Gancao.
关键词
芍药甘草汤 /
配伍 /
HPLC指纹图谱 /
药动学
{{custom_keyword}} /
Key words
Shaoyao-gancao decoction /
compatibility /
HPLC fingerprint /
pharmacokinetics
{{custom_keyword}} /
沈岚;冯怡;徐德生;林晓;张梁.
配伍前后芍药特征化学组分体内药动学变化研究[J]. 中国药学杂志, 2008, 43(23): 1774-1776
SHEN Ln;FENG Yi;XU De-sheng;LIN Xio;ZHNG Ling.
Pharmacokinetic Study on Characteristic Ingredients from Shaoyao before and after Compatibility [J]. Chinese Pharmaceutical Journal, 2008, 43(23): 1774-1776
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] FENG L Y，YAN S Q. Studies on analgesic action and mechanism of Shaoyao-gancao decoction[J] .Chin J Exp Tradit Med Form (中国实验方剂学杂志)，2002，8(1)：23-26．
[2] ZHANG L，XU D S，FENG Y.Study on adscription of plasma effective constituents of rat after administrated with Paeonia lacliflora and Glycyrrhiza uralensis compound[J] . China J Chin Mater Med(中国中药杂志)，2007，32(17)：1789-1791．
[3] GU Y，FENG Y.Research progress on substantial foundation and analgesic action effective part of Shaoyao-gancao decoction[J] . Lishizhen Med Mater Med Res(时珍国医国药)，2006，17（8）：1569-1570.
[4] HU S Z，CAI X L.Research on compatibility law of Shaoyao-gancao decoction[J] . Shanghai J Tradit Chin Med(上海中医药杂志)，1996，（11）：25.
[5] WANG J N，LIU G S . Pharmacological and clinical researches on analgesic action of Shaoyao-gancao decoction and its preparations[J] . Chin Tradit Pat Med（中成药），1999，21（9）：483-485.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
国家自然科学基金青年科学基金项目(30801548);上海市青年科技启明星计划(A类)项目(08QA14060);高等学校博士学科点专项科研基金项目(20060268009);上海市教委重点学科资助项目(J50302)
{{custom_fund}}
