糖胺聚糖衍生物在阿尔茨海默病治疗中的前景

杜晓光;李静;辛现良;刘红椿;耿美玉

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (23) : 1761-1764.

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (23) : 1761-1764.
综述

糖胺聚糖衍生物在阿尔茨海默病治疗中的前景

  • 杜晓光;李静;辛现良;刘红椿;耿美玉
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摘要

目的综述糖胺聚糖衍生物在阿尔茨海默病治疗中的前景。方法查阅国内外近年来大量文献,对阿尔茨海默病的发病机制、重要靶点和糖胺聚糖衍生物在阿尔茨海默病治疗中的应用进行分析和归纳。结果与结论淀粉样蛋白β(Aβ)与微管相关蛋白Tau是治疗老年痴呆的重要靶点,它们的神经毒作用与糖胺聚糖(glycosaminoglacan,GAGs)密切相关。而GAGs中糖链种类、分子聚合度、硫酸基的数目和位置等变动,将影响GAGs与APP,Aβ,Tau蛋白的结合位点、结合能力,从而引起不同的空间构象变化,发挥不同的生物学功能。因此深入研究GAGs与Aβ,Tau的构效关系和作用规律,通过对糖胺聚糖的分子结构改造有望开发出新的抗老年痴呆药物。

关键词

糖胺聚糖 / 淀粉样蛋白β / Tau / 老年痴呆

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导出引用
杜晓光;李静;辛现良;刘红椿;耿美玉. 糖胺聚糖衍生物在阿尔茨海默病治疗中的前景[J]. 中国药学杂志, 2008, 43(23): 1761-1764

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国家863计划资助项目(2005AA624020)

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