摘要
目的以岩黄连生物碱自乳化药物为模型,研究自微乳释药系统的制备及体外评价方法。方法制备岩黄连生物碱自微乳,以自微乳时间、所成微乳的形态、粒径分布、Zeta电位、含量、稳定性以及体外模拟人体释放等指标为考察项目,进行体外评价。结果所制备的自微乳载药量2.29 g·L-1,3 min内已基本乳化完全,乳化后粒子粒径大多数在20 nm左右,呈高斯分布,包封率大于98.7%,自微乳效率高。结论优选出的自乳化处方所制备的产品外观澄清透明,稳定性好,质量稳定,检测方法可靠,重现性好,展现了自微乳药物传统系统良好的释放特性。
Abstract
OBJECTIVE To study the preparation and in vitro evaluation of self-microemulsifying(SME) drug delivery system with alkaloids from Corydalis saxicola Bunting(CSBA).METHODS The Zeta potential,size distribution,dissolution and release in vitro of SME-CSBA were assessed.RESULTS SEM-CSBA was completely emulsificated within 3 min.Morphological studies revealed that nanospheres were spherical in shape about 20 nm and gaussian distribution.High drug encapsulation efficiency was obtained.CONCLUSION SME-CSBA prepared with optimization prescription is limpid,good stability,easy to prepare with consistent quality,whose reliable determination method may be easily reproduced.The SMEDDS showed good release profiles as drug delivery systems.
关键词
岩黄连生物碱 /
自微乳 /
制备 /
体外评价
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Key words
alkaloids from Corydalis saxicola Bunting /
self-microemulsifying drug delivery system /
preparation /
in vitro evaluation
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艾立;刘明星;刘清飞;王义明;罗国安.
岩黄连生物碱自微乳的制备及体外评价[J]. 中国药学杂志, 2008, 43(21): 1633-1637
I Li;LIU Ming-xing;LIU Qing-fei;WNG Yi-ming;LUO Guo-n.
Preparation and in Vitro Evaluation of Self-Microemulsifying Drug Delivery System with Alkaloids from Corydalis saxicola Bunting [J]. Chinese Pharmaceutical Journal, 2008, 43(21): 1633-1637
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参考文献
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脚注
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