OBJECTIVE To study the permention characteristics of gels contained scopolamine hydrobromide and /or galantamine hydrobromide in vitro.METHODS The penetrating experiments were performed by using rabbit skin and rat skin respectively on modified Franz diffusion cell.The contents of scopolamine hydrobromide and galantamine hydrobromide were determined by HPLC.RESULTS The determination drugs showed no interference with each other(P>0.05).The permention flux through rat skin of scopolamine hydrobromide in the different gels with scopolamine hydrobromide done and coexisted with galantamine hydrobromide were 104.66,170.96 μg·cm-2·h-1,respectively.The permeation rate through rabbit skin were 17.87,75.93 μg·cm-2·h-1.The permention flux through rat skin of galantamine hydrobromide in the different gels with scopolamine hydrobromide done and coexisted with scopolamine hydrobromide were 43.88,86.67 μg·cm-2·h-1.The permeation rate through rabbit skin were 26.49,75.49 μg·cm-2·h-1.CONCLUSION The permention flux in vitro will be enhanced by scopolamine hydrobromide coexisted with galantamine hydrobromide in gel.
CI Zhen;ZHU Qun-gng;CO Jing;LIU Yn-xi;HU Jin-hong.
Study on Permention Characteristics of Gels Contained Scopolamine Hydrobromide and Galantamine Hydrobromide in Vitro[J]. Chinese Pharmaceutical Journal, 2008, 43(21): 1629-1632
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参考文献
[1] ZHU Q G，HU J H，LU S W.The progress in research of prophyla- ctic agent against nerve agent poisoning[J] . J Toxicol（毒理学杂志），2007，21(3)：238-240.
[2] LALLEMENT G，FOQUIN A，DORANDEU F，et al. Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity[J] . Drug Chem Toxicol，2001，24(2)：165-180.
[3] LAYISH I，KRIVOY A，ROTMAN E，et al.Pharmacologic prophyl- axis against nerve poisoning[J] .Isr Med Assoc J，2005，7（3）：182-187.
[4] TANG J B，PING J B，PENG L B，et al. An analysis of the mar- ket prospect of galantamine[J] . China Pharm（中国药房），2006，17(22)：1690-1692.
[5] WHITE P F，TANG J，SONG D，et al. Transdermal scopo lami- ne： an alternative to ondansetron and droperidol for the prevention of postoperative and postdischarge emetic symptoms[J] . Anesth Analg，2007，104(1)：92-96.
[6] ZHENG H，SHI L F，HU J H.Preparation of sinomenine gel and its skin penetration test in vitro[J] . Pharm Care Res（药学服务与研究），2006，6(4)：271-273.
[7] CHEN H，CHEN Y，WANG H，et al. Analysis of scopolamine and its eighteen metabolites in rat urine by liquid chromatography-tandem mass spectrometry[J] .Talanta，2005，67(5)：984-991.
[8] ZU Q，ZHAO X L，DI L Q，et al. Comparison of percutaneous permeability of chuan xiong adhesive plaster on excised skins and synthetic membranes in vitro[J] . Jiangsu Pharm Clin Res（江苏药学与临床研究），2006，14(6)：358-360.
