摘要
目的测定表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)的人血浆蛋白结合率。方法采用超滤法对EGCG的血浆蛋白结合率进行测定。结果当质量浓度为5.0,10.0,20.0 mg·L-1时,EGCG平均血浆蛋白结合率分别为86.1%,91.4%,94.9%。结论EGCG与人血浆蛋白具有较强的结合。
Abstract
OBJECTIVE To determine epigallocatechin gallate(EGCG) protein binding rate with human plasma protein.METHODS Ultrafiltration was employed to determine protein binding rate of EGCG with human plasma.RESULTS The average human plasma protein binding rates of EGCG from the study were 86.1%,91.4% and 94.9% with plasma concentration of 5.0,10.0 and 20.0 mg·L-1,respectively.CONCLUSION EGCG has higher protein binding extent with human plasma.
关键词
表没食子儿茶素没食子酸酯 /
血浆蛋白结合率 /
超滤法 /
高效液相色谱法
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Key words
EGCG /
plasma protein binding rate /
ultrafiltration /
HPLC
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王立;任君刚.
超滤法测定表没食子儿茶素没食子酸酯人血浆蛋白结合率[J]. 中国药学杂志, 2008, 43(20): 1579-1581
WNG Li;REN Jun-gng.
Determination of Human Plasma Protein Binding of EGCG by Ultrafiltration [J]. Chinese Pharmaceutical Journal, 2008, 43(20): 1579-1581
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参考文献
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脚注
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