摘要
目的制备大剂量难溶性药物苯扎贝特单层渗透泵片,考察其释药的影响因素。方法以聚氧乙烯为载体和碳酸钠增溶相结合制备渗透泵片,并对影响释药的因素进行单因素考察。结果制备了大剂量难溶性药物苯扎贝特单层渗透泵片,聚氧乙烯主要影响释药的前期过程,而碳酸钠有助于最终释放完全。结论本渗透泵片使用了尽可能少的辅料,制备简便,能够达到12 h的恒速释放。
Abstract
OBJECTIVE To prepare bezafibrate Osmotic Pump Tablets and investigate the factors influencing the drug release.METHODS The Osmotic Pump Tablets were prepared with PEO as drug carriers and Na2CO3 as solubilizing agent.The factors that influenced drug release were examined by single factor investigation.RESULTS The water insoluble model drug of bezafibrate was prepared into Osmotic Pump Tablets.PEO had important effect on the early phase of drug release and Na2CO3 was conducive to the final release.CONCLUSION The preparation of osmotic pump of bezafibrate used small amount adjuvant,in addition,the drug release was stable during 12 h and had obvious characteristic of zero order release.
关键词
苯扎贝特 /
渗透泵片 /
大剂量难溶性药物 /
释放度
{{custom_keyword}} /
Key words
bezafibrate /
osmotic pump tablets /
insoluble drug with large dose /
drug release
{{custom_keyword}} /
吴蘅;杨星钢;张志宏;李伟;潘卫三.
大剂量难溶性药物苯扎贝特渗透泵片的研制[J]. 中国药学杂志, 2008, 43(20): 1574-1578
WU Heng;YNG Xing-gng;ZHNG Zhi-hong;LI Wei;PN Wei-sn.
Studies on Preparation of Osmotic Pump Tablets of Bezafibrate [J]. Chinese Pharmaceutical Journal, 2008, 43(20): 1574-1578
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] SANTUS G，BAKER R W. Osmotic drug delivery： A review of the patent literature [J] .J Controlled Release，1995，35 (1)：1-21.
[2] LIU L X，XU Q，JIANG J S，et al.Unitary-core osmotic pump tablet for controlled release of water-insoluble drug[J] .Acta Pham Sin (药学学报)，2003，38 (12)：966-967.
[3] PRABAKARAN D，SINGH P，KANAUJIA P. Modified push-pull osmotic system for simultaneous delivery of theophylline and salbutamol： development and in vitro characterization[J] . Int J Pharm，2004，284 (1-2)：95-108.
[4] THOMBRE A G. Osmotic drug delivery using swellable-core tech- nology [J] . J Controlled Release，2004，94，(1)：75-89.
[5] MONK J P， TODD P A. Bezafibrate： A review of its pharmac-odynamic and pharmacokinetic properties and therapeutic use in hyperlipidaemia[J] . Drugs，1987，33 (6)： 539-576.
[6] LIU C H，XU X Y，CHEN Y，et al. Preparation and in vitro/ in vivo evaluation of bezafibrate sustained-release pellet capsules [J] . J China Pharm Univ (中国药科大学学报)，2006，37 (5)：419- 422.
[7] LI X D，PAN W S，NIE S F，et al. Studies on controlled release effervescent osmotic pump tablets from Traditional Chinese Medicine Compound Recipe [J] . J Controlled Release，2004，96 (3)：359-367.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
